Subscribe Now Subscribe Today
Science Alert
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2010 | Volume: 13 | Issue: 20 | Page No.: 966-976
DOI: 10.3923/pjbs.2010.966.976
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Efficacy of Echinacea on the Action of Cyproterone Acetate in Male Rats

Nadia M.S. Arafa

The study aimed to evaluate the effect Echinacea extract (E) on the testicular antioxidants function in normal rats or that subjected to anti-androgenic compound, cyproterone acetate (CA). Rats were divided into 5 groups treated daily via an oral tube for two intervals 2 and 4 weeks, 1st control, 2nd E (Echinacea treated group in dose 63 mg kg-1), 3rd CA (cyproterone acetate treated group in dose 25 mg kg-1), 4th E+CA and 5th E as prophylactic one week before E+CA treatment with the same aforementioned E or CA doses. The body, testes, epididymis and vas deferens weights were recorded. Sperm count, Nitric Oxide (NO), calcium ion (Ca2+) and malondialdhyde (MDA) contents in addition to superoxide dismutase (SOD), glutathione S-transferase (GST) activities were determined in testicular tissues. CA exhibited direct negative effect on reproductive organs weight and significant reducing effect on sperm count and Ca2+ contents. SOD and GST activities significantly decreased in addition to significant increase in NO, MDA contents reflecting the oxidative status of testis in CA treated rats. The prophylactic effect of E treatment, in time related manner, showed significant improvement in the antioxidant status of the testicular tissue which is more pronounced as compared to E+CA treatment.
PDF Fulltext XML References Citation Report Citation
  •    Anti-spermatogenic Activity of Leptadenia hastata (Pers.) Decne Leaf Stems Aqueous Extracts in Male Wistar Rats
How to cite this article:

Nadia M.S. Arafa , 2010. Efficacy of Echinacea on the Action of Cyproterone Acetate in Male Rats. Pakistan Journal of Biological Sciences, 13: 966-976.

DOI: 10.3923/pjbs.2010.966.976






Curve Bottom