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Pakistan Journal of Biological Sciences
  Year: 2010 | Volume: 13 | Issue: 20 | Page No.: 966-976
DOI: 10.3923/pjbs.2010.966.976
 
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Efficacy of Echinacea on the Action of Cyproterone Acetate in Male Rats

Nadia M.S. Arafa

Abstract:
The study aimed to evaluate the effect Echinacea extract (E) on the testicular antioxidants function in normal rats or that subjected to anti-androgenic compound, cyproterone acetate (CA). Rats were divided into 5 groups treated daily via an oral tube for two intervals 2 and 4 weeks, 1st control, 2nd E (Echinacea treated group in dose 63 mg kg-1), 3rd CA (cyproterone acetate treated group in dose 25 mg kg-1), 4th E+CA and 5th E as prophylactic one week before E+CA treatment with the same aforementioned E or CA doses. The body, testes, epididymis and vas deferens weights were recorded. Sperm count, Nitric Oxide (NO), calcium ion (Ca2+) and malondialdhyde (MDA) contents in addition to superoxide dismutase (SOD), glutathione S-transferase (GST) activities were determined in testicular tissues. CA exhibited direct negative effect on reproductive organs weight and significant reducing effect on sperm count and Ca2+ contents. SOD and GST activities significantly decreased in addition to significant increase in NO, MDA contents reflecting the oxidative status of testis in CA treated rats. The prophylactic effect of E treatment, in time related manner, showed significant improvement in the antioxidant status of the testicular tissue which is more pronounced as compared to E+CA treatment.
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How to cite this article:

Nadia M.S. Arafa , 2010. Efficacy of Echinacea on the Action of Cyproterone Acetate in Male Rats. Pakistan Journal of Biological Sciences, 13: 966-976.

DOI: 10.3923/pjbs.2010.966.976

URL: https://scialert.net/abstract/?doi=pjbs.2010.966.976

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