• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Pakistan Journal of Biological Sciences
  2. Vol 13 (16), 2010
  3. 785-793
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Pakistan Journal of Biological Sciences

Year: 2010 | Volume: 13 | Issue: 16 | Page No.: 785-793
DOI: 10.3923/pjbs.2010.785.793

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 592

Search


Authors


P. Anand

Country: India

D. Rajakumar

Country: India

A. John William Felix

Country: India

T. Balasubramanian

Country: India

Keywords


  • Free radical
  • Platelet count
  • MCH
  • MCHC
  • neutrophil
  • lymphocyte
  • lysozyme
Research Article

Effects of Oral Administration of Antioxidant Taurine on Haematological Parameters in Wistar Rats

P. Anand, D. Rajakumar, A. John William Felix and T. Balasubramanian
The present study evaluates the effects of oral administration of taurine on haematological parameters in normal wistar rats. Tissue oxidative stress is implicated in pathogenesis of various clinical disorders and antioxidant taurine is emerging as prophylactic and therapeutic agent. However, studies on effects of taurine on normal physiology are not reported in literature. Normal saline (Group I) or 5% taurine in normal saline was administered in dose of 50 mg (Group II), 250 mg (Group III) or 500 mg kg-1 of b.wt. (Group IV) through intragastric intubation for 60 days. The blood cell counts, haemoglobin content, packed cell volume, blood indices, bleeding time and clotting time were estimated using routine laboratory haematological techniques. Neutrophil’s phagocytic activity was determined by nitroblue tetrazolium reduction test; serum lysozyme activity was estimated colorimetrically by the degree to lyse bacterial cell suspension and serum taurine levels were estimated by HPLC fluorimetric technique. Platelet count showed a decrease in Group III and IV when compared with Group I and II (p<0.001). Mean corpuscular haemoglobin of Group III and IV are significantly lowered when compared to Group I (p<0.001). A statistically significant decrease was observed in the mean corpuscular haemoglobin concentration between Group I and Group IV (p<0.001). The neutrophil percentage of Group II, Group III and Group IV showed a significant increase over Group I (p<0.001). The percentage of lymphocytes showed a significant decrease in Group II, III and Group IV when compared to Group I (p<0.001). Neutrophil’s phagocytic activity is significantly lowered in Group III and IV when compared to Group I (p<0.001). The serum lysozyme activity of Group III and IV showed a significant increase over Group I (at p<0.001). From the present study it may be concluded that long term oral administration of taurine affects normal haematological functions.
PDF Fulltext XML References Citation

How to cite this article

P. Anand, D. Rajakumar, A. John William Felix and T. Balasubramanian, 2010. Effects of Oral Administration of Antioxidant Taurine on Haematological Parameters in Wistar Rats. Pakistan Journal of Biological Sciences, 13: 785-793.

DOI: 10.3923/pjbs.2010.785.793

URL: https://scialert.net/abstract/?doi=pjbs.2010.785.793

Related Articles

Effects of Taurine on Glutathione Peroxidase, Glutathione Reductase and Reduced Glutathione Levels in Rats
Prevention of Alloxan Induced Diabetes Mellitus in Rats by Vitamin a Dietary Supplementation
Anti-Ulcerogenic Activity of Two Extracts of Parquetina nigrescens and their Effects on Mucosal Antioxidants Defence System on Ethanol-Induced Ulcer in Rats

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved