Prevention of Selenite-induced Cataractogenesis by Origanum vulgare Extract


	Pakistan Journal of Biological Sciences
	Year: 2010 \| Volume: 13 \| Issue: 15 \| Page No.: 743-747 DOI: 10.3923/pjbs.2010.743.747

Prevention of Selenite-induced Cataractogenesis by Origanum vulgare Extract

K.N. Dailami, M. Azadbakht, Z.R. Pharm and M. Lashgari

Abstract: The present study sought to assess antioxidant effect of Origanum vulgare extract in preventing selenite-induced cataractogenesis. This study was performed on Young white rats received sodium selenite (30 nmol g^-1 birth weight) subcutaneously on day 13 post partum during two months in 2009. Cataract formation and intensity was detected and measured by slit-lamp. Origanum vulgare (Ov) extract (2 g kg^-1) was given (1-2 times) intraperitoneal at different times with respect to the selenite administration lens opacification was analyzed in selenite, selenite-Ov, Ov and control groups on day 7 after selenite administration. Ov extract have revealed a significant protective effect against selenite induced cataract when injected 1 and 2 day (2 times) before selenite injection. There is a protective effect of Ov against selenite induced cataract formation. It is supposed that the anticataract effect of Ov extract could be based on direct or indirect antioxidant mechanisms.

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How to cite this article:

K.N. Dailami, M. Azadbakht, Z.R. Pharm and M. Lashgari, 2010. Prevention of Selenite-induced Cataractogenesis by Origanum vulgare Extract. Pakistan Journal of Biological Sciences, 13: 743-747.

DOI: 10.3923/pjbs.2010.743.747

URL: https://scialert.net/abstract/?doi=pjbs.2010.743.747

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