Submit Manuscript

Pakistan Journal of Biological Sciences

Year: 2010 | Volume: 13 | Issue: 24 | Page No.: 1214-1218
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 185

Authors

A. Nourozi

H. Talebi

S. Fateh

A. Mohammadzadeh

P. Eghtesadi-Araghi

Z. Ahmadi

A. Savarabadi

A. Mohebbi

Keywords

To determine the effect of adding ketamine to pethidine in reducing post-operative pain in patients undergoing major abdominal operations, in a double blind randomized controlled trial, 100 patients aged 15-60 years who were candidate for elective major abdominal surgery allocated into two groups of pethidine + ketamine group (5 mg pethidine and 0.25 mg kg-1 ketamine) or pethidine and placebo group (10 mg pethidine and NS) according to the regimen prescribed in postanesthesia care unit. Severity of pain (using visual analogue scale), prescribed dose of pethidine and side effects were recorded until 24 h after operation. Regarding post-operative pain, pethidine + ketamine group showed significant lower scores in all the times except 0 min, 2, 6 and 16 h. Nausea was significantly less frequent amongst pethidine + placebo group at times of 0, 15, 30 and 45 min (p<0.05). Comparison of two groups did not show significant differences in prescribed pethedine dose in 0, 9, 12, 16, 20 and 24 h (p>0.05). Yet, the mean dose of administered pethidine as rescue analgesic was significant lower in pethidine + ketamine group compared to pethidine + placebo group (112±31.5 mg vs. 133.5±24.5 mg, p<0.001). In conclusion, our results showed that co-administration of ketamine and pethidine in postanesthesia care unit will improve postoperative pain and reduce narcotic consumption. It may, however, increase rate of postoperative nausea in the first hour after operation.
PDF Fulltext XML References Citation

How to cite this article

A. Nourozi, H. Talebi, S. Fateh, A. Mohammadzadeh, P. Eghtesadi-Araghi, Z. Ahmadi, A. Savarabadi and A. Mohebbi, 2010. Effect of Adding Ketamine to Pethidine on Postoperative Pain in Patients undergoing Major Abdominal Operations: A Double Blind Randomized Controlled Trial. Pakistan Journal of Biological Sciences, 13: 1214-1218.

DOI: 10.3923/pjbs.2010.1214.1218

URL: https://scialert.net/abstract/?doi=pjbs.2010.1214.1218

Leave a Comment

Your email address will not be published. Required fields are marked *