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Pakistan Journal of Biological Sciences
  Year: 2009 | Volume: 12 | Issue: 16 | Page No.: 1160-1163
DOI: 10.3923/pjbs.2009.1160.1163
 
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CYP2C9 Gene Analysis of Some Iranian Hypersensitive Patients to Warfarin

P. Ghadam, R. Sharifian, Z. Jomeh Farsangi, Z. Kianmehr and M. Lak

Abstract:
For the first time in this study, the pharmacogenetic effects of CYP2C9 polymorphism on warfarin sensitivity in some Iranian patients who are on warfarin treatment were shown. The study group consisted of clinically sensitive patients(21 patients) and the control group (37 adult patients). For detection of CYP2C9*2 and CYP2C9*3 variants, a protocol based on restriction fragment length polymorphism based polymerase chain reaction with Eco47I and KpnI was used. In clinically sensitive patients about 81% and in normal response patients about 24.3% carried variant genotypes.
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How to cite this article:

P. Ghadam, R. Sharifian, Z. Jomeh Farsangi, Z. Kianmehr and M. Lak, 2009. CYP2C9 Gene Analysis of Some Iranian Hypersensitive Patients to Warfarin. Pakistan Journal of Biological Sciences, 12: 1160-1163.

DOI: 10.3923/pjbs.2009.1160.1163

URL: https://scialert.net/abstract/?doi=pjbs.2009.1160.1163

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