Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2008 | Volume: 11 | Issue: 4 | Page No.: 638-642
DOI: 10.3923/pjbs.2008.638.642
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Effects of Short and Long Term Treatment of Ballota undulate on Female Albino Rats Fertility and Pregnancy
Walid Sh. Qazan

Abstract: The objectives of this study is to investigate the toxic effects of Ballota undulata (300 mg kg-1 b.wt.) on the reproductive system after administration to female Sprague-Dawley rats for two time periods 4 and 12 weeks. Forty adult female Sprague-Dawley rats were divided into two treatment and two control groups of 10 rats each. The two treated groups received 15 mg kg-1 b.wt. of Ballota undulata for two periods of 4 and 12 weeks. Female rats were allowed mating with males after treatment. Several pregnancy parameters were investigated including: total number of pregnant rats, body weight and reproductive organ weight, number of implantation sites, number of resorption sites and number of viable fetuses. The significance of these results was calculated using student's t and Chi-square tests. Exposure to Ballota undulata for 4 weeks did not have significant effects on most parameters investigated. However, a slight decrease in the relative ovarian and embryo weights was observed. Administration of Ballota undulata for 12 weeks significantly reduced the percentage of pregnancies and the number of implantation sites when compared with controls. In addition, a decrease in ovarian weights and in viable fetuses` number was also observed. Histological sections of ovaries of female treated with Ballota undulata were found to have congested blood vessels in cortical and medullary regions. We also noted the arrestment of developing follicles at primary and secondary stages in addition to presence of degenerative areas and hypercellullarity in medulla. Long term treatment with Ballota undulata might lead to diversified negative effects on fertility and pregnancy in female rats.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Walid Sh. Qazan , 2008. Effects of Short and Long Term Treatment of Ballota undulate on Female Albino Rats Fertility and Pregnancy. Pakistan Journal of Biological Sciences, 11: 638-642.

DOI: 10.3923/pjbs.2008.638.642

URL: https://scialert.net/abstract/?doi=pjbs.2008.638.642
COMMENT ON THIS PAPER
 
 
 

 
  Bullet Navigation
 
  Page Icon Online First
  Page Icon Current Issue
  Page Icon Previous Issues
  Page Icon Editorial Board
  Page Icon Submit a Manuscript
  Page Icon Guide to Authors
  Page Icon Subscribe to E-alerts

  Bullet Indexed In
 
  Page Icon AGRIS
  Page Icon ASCI-Database
  Page Icon Asian Digital Library
  Page Icon Cambridge Scientific Abstract
  Page Icon Chemical Abstract Services
  Page Icon Google Scholar
  Page Icon ISI Web of Knowledge
  Page Icon PubMed
  Page Icon SCIMAGO
  Page Icon Thomson ISI

Science Alert
Curve Bottom