• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Pakistan Journal of Biological Sciences
  2. Vol 11 (2), 2008
  3. 312-314
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Pakistan Journal of Biological Sciences

Year: 2008 | Volume: 11 | Issue: 2 | Page No.: 312-314
DOI: 10.3923/pjbs.2008.312.314

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 92

Authors


Hossein Tajik

Country: Iran

Esmaeal Tamaddonfard

Country: Iran

Nasrin Hamzeh-Gooshchi

Country: Iran

Keywords


  • Curcumin
  • morphine
  • naloxone
  • rats
  • turmeric
  • visceral nociception
Research Article

The Effect of Curcumin (Active Substance of Turmeric)on the Acetic Acid-Induced Visceral Nociception in Rats

Hossein Tajik, Esmaeal Tamaddonfard and Nasrin Hamzeh-Gooshchi

In the present study, the effect of chronic oral administration of curcumin in the presence or absence of morphine and noloxone was investigated on the visceral nociception induced by acetic acid in rats. Intraperitoneal injection of acetic acid (1 mL, 2%) produced contractions in the abdominal musculature (writhes). The latency time to the beginning of the first writhe was measured and the total number of writhes in the 1 h after acetic acid injection was counted. The latency time to the beginning of the first writhe was significantly (p<0.05) increased and the number of writhes was significantly (p<0.05) decreased by curcumin (20 and 40 mg kg-1 body weight). The same results were obtained after subcutaneous injection of morphine (1 mg kg-1 b.wt.). Naloxone at the dose of 1 mg kg-1 body weight had no effect on pain intensity. Curcumin significantly (p<0.05) enhanced the effect of morphine on the visceral pain responses, however did not reverse the effect of naloxone. Present data suggest that in the acetic acid-induced visceral nociception of rats, curcumin may produce an antinociceptive effect and the endogenous analgesic opioid system is involved in the curcumin-induced antinociception.


PDF Fulltext XML References Citation

How to cite this article

Hossein Tajik, Esmaeal Tamaddonfard and Nasrin Hamzeh-Gooshchi, 2008. The Effect of Curcumin (Active Substance of Turmeric)on the Acetic Acid-Induced Visceral Nociception in Rats. Pakistan Journal of Biological Sciences, 11: 312-314.

DOI: 10.3923/pjbs.2008.312.314

URL: https://scialert.net/abstract/?doi=pjbs.2008.312.314

Related Articles

Curcumin-The Yellow Magic

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved