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Pakistan Journal of Biological Sciences
  Year: 2008 | Volume: 11 | Issue: 22 | Page No.: 2584-2588
DOI: 10.3923/pjbs.2008.2584.2588
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Urinary Protein Assessment in Preeclampsia: Which Sample is More Suitable?

N. Moslemizadeh, K. Yousefnejad, T. Galini Moghadam and S. Peyvandi

Mild or severe preeclampsia is responsible for about 70% of hypertensive disorders observed during pregnancy and 24 h urine collection is a gold standard for diagnosis of preeclampsia. This study was performed to determine whether the gold standard of 24 h urine protein value in pre-eclampsia can be substituted with 8 or 12 h urine protein values and to evaluate the effect of ambulation and immobilization on amount of protein excretion. A cross sectional study was conducted on 40 women with pre-eclampsia (BP≥140/90 mmHg), who referred to the Department of Obstetric and Gynecology, Imam Khomeiny hospital in Sari, Iran from April 2005 to September 2005. Positive urinary strip for protein of at least 1+ samples were collected over 24 h in subsequent periods: the first 8 h and the next 4 h and remaining 12 h urine, in separate containers. The correlation between groups was determined by Pearson`s correlation. A total of 40 women were recurited in this study of which 36 had completed urine collection. A total of 21 had mild proteinuria, 5 had severe proteinuria and 10 had no proteinuria. There was significant correlation between the 8 or 12 h (day) and 12 h (night) with 24 h urine protein. Total protein values of 8 and 12 h (day) and 12 h (night) samples, positively correlated with values of 24 h samples in pre-eclampsia and could be substituted for assessment of proteinuria instead of 24 h urine collection in women with pre-eclampsia, as a simpler, faster and cheaper method for diagnosis of pre-eclampsia. And ambulation and immobilization in preeclamptic patients has not any effect on protein excretion.
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How to cite this article:

N. Moslemizadeh, K. Yousefnejad, T. Galini Moghadam and S. Peyvandi, 2008. Urinary Protein Assessment in Preeclampsia: Which Sample is More Suitable?. Pakistan Journal of Biological Sciences, 11: 2584-2588.

DOI: 10.3923/pjbs.2008.2584.2588






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