Identification of Cytotoxic Compound from Artocarpus communis Leaves Against P-388 Cells


	Pakistan Journal of Biological Sciences
	Year: 2008 \| Volume: 11 \| Issue: 21 \| Page No.: 2517-2520 DOI: 10.3923/pjbs.2008.2517.2520

Identification of Cytotoxic Compound from Artocarpus communis Leaves Against P-388 Cells

Puspa D.N. Lotulung, Sofa Fajriah, Muhammad Hanafi and Euis Filaila

Abstract: In the course of continuing research for finding bioactive compounds from Indonesian plants, the leaves of Artocarpus communis was extracted by ethanol. This extract partitioned with n-hexane-water (1:4) and then water extract was partitioned with dichloromethane. Dichloromethane extract was purified by column chromatography techniques on silica gel to afford yellow crystal (F-1). Based on LC-MS, ¹H-NMR and ¹³C-NMR (1D and 2D) spectra and compared with previous spectral data, it was identified as prenylated flavonoid, 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl] 1-propanone. This compound showed significant cytotoxicity against murine P-388 leukemia cells.

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How to cite this article:

Puspa D.N. Lotulung, Sofa Fajriah, Muhammad Hanafi and Euis Filaila, 2008. Identification of Cytotoxic Compound from Artocarpus communis Leaves Against P-388 Cells. Pakistan Journal of Biological Sciences, 11: 2517-2520.

DOI: 10.3923/pjbs.2008.2517.2520

URL: https://scialert.net/abstract/?doi=pjbs.2008.2517.2520

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