Identification of Cytotoxic Compound from Artocarpus communis Leaves Against P-388 Cells


	Pakistan Journal of Biological Sciences
	Year: 2008 \| Volume: 11 \| Issue: 21 \| Page No.: 2517-2520 DOI: 10.3923/pjbs.2008.2517.2520

Identification of Cytotoxic Compound from Artocarpus communis Leaves Against P-388 Cells

Puspa D.N. Lotulung, Sofa Fajriah, Muhammad Hanafi and Euis Filaila

Abstract: In the course of continuing research for finding bioactive compounds from Indonesian plants, the leaves of Artocarpus communis was extracted by ethanol. This extract partitioned with n-hexane-water (1:4) and then water extract was partitioned with dichloromethane. Dichloromethane extract was purified by column chromatography techniques on silica gel to afford yellow crystal (F-1). Based on LC-MS, ¹H-NMR and ¹³C-NMR (1D and 2D) spectra and compared with previous spectral data, it was identified as prenylated flavonoid, 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl] 1-propanone. This compound showed significant cytotoxicity against murine P-388 leukemia cells.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Indonesian Kepel Fruit (Stelechocarpus burahol) as Oral Deodorant

How to cite this article:

Puspa D.N. Lotulung, Sofa Fajriah, Muhammad Hanafi and Euis Filaila, 2008. Identification of Cytotoxic Compound from Artocarpus communis Leaves Against P-388 Cells. Pakistan Journal of Biological Sciences, 11: 2517-2520.

DOI: 10.3923/pjbs.2008.2517.2520

URL: https://scialert.net/abstract/?doi=pjbs.2008.2517.2520

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar
		ISI Web of Knowledge
		PubMed
		SCIMAGO
		Thomson ISI