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Pakistan Journal of Biological Sciences
  Year: 2008 | Volume: 11 | Issue: 20 | Page No.: 2447-2450
DOI: 10.3923/pjbs.2008.2447.2450
 
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Antioxidant Compound from the Rhizomes of Kaempferia rotunda L.

Puspa D.N. Lotulung, Minarti , L.B.S. Kardono and K. Kawanishi

Abstract:
This research aimed to investigate the antioxidant effect from rhizomes of K. rotunda for finding the active compounds by DPPH free radical scavenging activity assay. The chloroform-soluble extract of the rhizomes of K. rotunda showed significant scavenging effect on the on 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radicals (IC50 = 180 μg mL-1). Two compounds of the chloroform-soluble extract were isolated and identified. Compound 1, 2`-hydroxy-4,4`,6`-trimethoxy-chalcone was found as the active constituent (IC50 = 142 μg mL-1). Compound 2, (+)-crotepoxide, was inactive (IC50= 1516 μg mL-1). The structures of compounds 1 and 2 were identified based on the basis of spectral evidence, Mass Spectrophotometry (MS) and 2D-NMR (2 dimension of Nuclear Magnetic Resonance) data including Heteromolecular Multiple Quantum Coherence (HMQC) and Heteromolecular Multiple Bond Correlation (HMBC) and comparison to published values.
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How to cite this article:

Puspa D.N. Lotulung, Minarti , L.B.S. Kardono and K. Kawanishi, 2008. Antioxidant Compound from the Rhizomes of Kaempferia rotunda L.. Pakistan Journal of Biological Sciences, 11: 2447-2450.

DOI: 10.3923/pjbs.2008.2447.2450

URL: https://scialert.net/abstract/?doi=pjbs.2008.2447.2450

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