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Antimicrobial Susceptibility Pattern of Microorganisms Involved
in the Pathogenesis of Surgical Site Infection (SSI); A 1 Year of Surveillance |
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F. Khorvash,
K. Mostafavizadeh,
S. Mobasherizadeh,
M. Behjati,
A. E. Naeini,
S. Rostami,
S. Abbasi,
M. Memarzadeh and F. A. Khorvash |
Abstract:
The aim of this study is to identify the antibiotic sensitivity pattern
of pathogens involved in the process of surgical site infection, in surgical
wards. Changes made in the pattern of antibiotic use will result in different
microorganism susceptibility patterns, which needs correct determination
for precise empiric antibiotic therapy. One thousand patients (62% men
and 38% women, 18-74 years old, with mean age 43±8)) who underwent
surgical treatment, in Alzahra University Hospital, Isfahan University
of Medicine, Isfahan, Iran, were studied from 2005 to 2006. Surgical wound
infections, based on the reported criteria, were aspirated for culturing
within 1 plus gram staining of prepared smears. Minimum Inhibitory Concentrations
(MICs) were determined for samples and all derived data were compared
by SPSS 13 and WHO net 5 software. The prevalence of SSI was 13.3% with
150 positive cultures, totally. Of 150 bacteria, isolated from surgical
site infections Staphylococcus aureus had most frequency (43%).
Resistance of isolated organisms was 41.7% in amikacin, 65 and 78.6% in
ceftazidime, 85.7% in ceftriaxone, 61.5% in ciprofloxacin, 78.8% in gentamicine,
6.4% in imipenem, 13% in meropenem and 70.6% in trimethoprim/sulfamethoxazole,
respectively. 78.9% of Staphylococcus aureus isolates were MRSA
and vancomycine was the most effective antibiotic without any resistance.
Among 10 isolates of coagulase negative Staphylococcus, no vancomycine
resistance was seen, but in contrast all cases were resistant to oxacillin.
The most common gram negative organism was Klebsiella (18 isolates)
in which 100 and 80% were sensitive to imipenem and meropenem, respectively.
Seventeen cases were E. coli, in which the most sensitivity was
to meropenem (80%) and imipenem (77.8%). Thirteen cases of Pseudomonas
were detected, in which 16.7% were resistant to imipenem and 8.3% to meropenem.
Our results demonstrated that the total antibiotic resistance is increasing
among SSIs, with an up sloping pattern, which will contact with a constant
empiric antibiotic therapy. So, precise up to date antibiogram tantalize
us toward balancing the rate of total antibiotic resistance to SSIs.
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How to cite this article:
F. Khorvash, K. Mostafavizadeh, S. Mobasherizadeh, M. Behjati, A. E. Naeini, S. Rostami, S. Abbasi, M. Memarzadeh and F. A. Khorvash, 2008. Antimicrobial Susceptibility Pattern of Microorganisms Involved
in the Pathogenesis of Surgical Site Infection (SSI); A 1 Year of Surveillance. Pakistan Journal of Biological Sciences, 11: 1940-1944.
DOI: 10.3923/pjbs.2008.1940.1944
URL: https://scialert.net/abstract/?doi=pjbs.2008.1940.1944
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