Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2008 | Volume: 11 | Issue: 14 | Page No.: 1779-1784
DOI: 10.3923/pjbs.2008.1779.1784
Effects of Onion on Serum Uric Acid Levels and Hepatic Xanthine Dehydrogenase/Xanthine Oxidase Activities in Hyperuricemic Rats
Fatemeh Haidari, Mohammad Reza Rashidi, Seid Ali Keshavarz, Soltan Ali Mahboob, Mohammad Reza Eshraghian and Majid Mohamad Shahi

Abstract:
The aim of this study was to investigate the effects of onion on serum uric acid levels and hepatic Xanthine Dehydrogenase/Xanthine Oxidase activities in normal and hyperuricemic rats. Hyperuricemia was induced by intraperitoneal injection of 250 mg kg-1 potassium oxonate in rats. Oral administration of onion at 3.5 and 7.0 mg kg-1 day-1 for 7 days was able to reduce serum uric acid levels in hyperuricemic rats with no significant effects on the level of this compound in the normal animals. In addition, onion when tested in vivo on rat liver homogeneities elicited significant inhibitory actions on the Xanthine Dehydrogenase (XDH) and Xanthine Oxidase (XO) activities. This effect resulted less potent than that of allopurinol. However, the hypouricemic effect observed in the experimental animal did not seem to parallel the change in XDH and XO activities, implying that the onion might be acting via other mechanisms apart from simple inhibition of enzyme activities. Such hypouricemic action and enzyme inhibitory activity of onion makes it a possible alternative for allopurinol, or at least in combination therapy to minimize the side-effects of allopurinol, in particular in long-term application.
 [Fulltext PDF]   [Fulltext HTML]   [XML: Abstract + References]   [References]   [View Citation]  [Report Citation]
 RELATED ARTICLES:
  •    Anti-hyperuricemic, Uricosuric and Xanthine-oxidase Inhibitory Activities of Watermelon Powder in a Rat Gout Model
  •    Synergistic Influence of Tetracycline on the Antibacterial Activities of Amoxicillin Against Resistant Bacteria
  •    Onion (Allium cepa L.): An Alternate Medicine For Pakistani Population
  •    Production and Partial Characterization of Uric Acid Degrading Enzyme from New Source Saccharopolyspora sp. PNR11
How to cite this article:

Fatemeh Haidari, Mohammad Reza Rashidi, Seid Ali Keshavarz, Soltan Ali Mahboob, Mohammad Reza Eshraghian and Majid Mohamad Shahi, 2008. Effects of Onion on Serum Uric Acid Levels and Hepatic Xanthine Dehydrogenase/Xanthine Oxidase Activities in Hyperuricemic Rats. Pakistan Journal of Biological Sciences, 11: 1779-1784.

DOI: 10.3923/pjbs.2008.1779.1784

URL: https://scialert.net/abstract/?doi=pjbs.2008.1779.1784

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

Curve Bottom