Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2008 | Volume: 11 | Issue: 2 | Page No.: 153-163
DOI: 10.3923/pjbs.2008.153.163
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Light and Electron Microscopic Studies on the Effect of a Contraceptive Drug on the Stomach of Mouse

Fatma A. Elhumeed and Wafaa B. Yousif

Abstract:

The present study was an investigation of the effect of the contraceptive drug, Nordette, on the stomach of the mouse when administered daily at a recommended therapeutic dose rate of 0.0026 mg kg-1 for 30 days. Extensive light and electron microscopic changes were noticed. The drug caused enlargement in the all types of cells. The oxyntic cells appeared hypertrophied with irregular cell boundaries, enlarged nuclei and faintly stained cytoplasm. Their cytoplasm contained irregularly distributed mitochondria with dense matrix, decreased rER, obviously increased sER, disorganized intracellular canaliculi and some lysosomes. The peptic cells appeared enlarged and contained hypertrophied rough endoplasmic reticulum and an increase amount of ribosomes and secretory granules. There was an increase in the amount of the secretory granules in the lumen of the gastric gland. The mucus cells at the upper region of the gastric gland were greatly decreased. Smooth muscle fibers showed enlargement and degeneration. The submucosa and lamina propria showed vacuolation. The most pathological effects were restricted to the obvious decrease of the lymphoid cells in the submucosa and lamina propria. Dilatation and congestion of the blood vessels and blood capillaries were noticed. Blood capillaries lined by enlarged endothelial cells containing enlarged heterochromatic nuclei.

PDF Fulltext XML References Citation Report Citation
How to cite this article:

Fatma A. Elhumeed and Wafaa B. Yousif, 2008. Light and Electron Microscopic Studies on the Effect of a Contraceptive Drug on the Stomach of Mouse. Pakistan Journal of Biological Sciences, 11: 153-163.

DOI: 10.3923/pjbs.2008.153.163

URL: https://scialert.net/abstract/?doi=pjbs.2008.153.163

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

Curve Bottom