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Pakistan Journal of Biological Sciences
  Year: 2008 | Volume: 11 | Issue: 8 | Page No.: 1152-1156
DOI: 10.3923/pjbs.2008.1152.1156
 
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The Effect of Levamisole on Sheep Trachea Alone and With Trichlorfon Combination

Emine Baydan, Ebru Yildirim and Sinan Ince

Abstract:
The aim of this study is to determine the effect of levamisole and levamisole-trichlorfon combination on isolated sheep trachea. Contraction was achieved with levamisole concentrations (10-8-10-3 M) on tracheal strips of adult sheep (>1 year of age). Pretreatment with trichlorfon (10-7 M)-levamisole (10-7 M) decreased the pD2 and Emax of Ach when compared to levamisole pretreatment (p<=0.01). Pretreatment with levamisole (10-7 M), decreased the Emax (p<=0.01) and pD2 (p<0.05) of bethanechol concentrations (10-8-10-3 M) significantly. Pretreatment with atropine (10-6 M) decreased the Emax of levamisole (10-4 M) significantly (p<0.05). To conclude, levamisole acted mainly on the muscarinic receptors of the sheep trachea and this effect was partly inhibited by atropine. Adverse interaction was present between levamisole and trichlorfon.
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How to cite this article:

Emine Baydan, Ebru Yildirim and Sinan Ince, 2008. The Effect of Levamisole on Sheep Trachea Alone and With Trichlorfon Combination. Pakistan Journal of Biological Sciences, 11: 1152-1156.

DOI: 10.3923/pjbs.2008.1152.1156

URL: https://scialert.net/abstract/?doi=pjbs.2008.1152.1156

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