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Pakistan Journal of Biological Sciences
  Year: 2007 | Volume: 10 | Issue: 22 | Page No.: 4168-4170
DOI: 10.3923/pjbs.2007.4168.4170
 
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Pharmacokinetic of Sulfisoxazole in Aqueous Humor after Topical and Subconjunctival Application in Dogs

Gokhan Eraslan, Murat Kibar , Dinc Essiz , Fatma Sahindokuyucu and Bilal Cem Liman

Abstract:
This study was undertaken to evaluate the ocular pharmacokinetic of sulfisoxazole. Male, 2-3 years old 10 mix breed dogs weighing 12-15 kg were used. A 2 mg dose/eye of sulfisoxazole was administrated to the animals by either subconjunctivally or by topically. Samples of aqueous humor were collected after 0.083, 0.25, 0.5, 1, 2, 4, 6, 24 and 72 h and level of sulfisoxazole was determined. Pharmacokinetic parameters including absorption rate constant (ka), slope factor (β), absorption half-life (t1/2a), half-life of elimination in aqueous humor (t1/2β), maximal concentration in aqueous humor (Cmax), time to reach Cmax (tmax), mean residence time in aqueous humor (MRT) and area under the concentration time curve from zero up to ∞ (AUC0→4) were calculated. Compared to topical application, value of ka in subconjunctival application increased while values of t1/2a and tmax decreased and the value of t1/2β prolonged (p<0.05). There was no significant difference between groups regarding other parameters (p>0.05). These results indicate that sulfisoxazole may not be potent enough to treat intraocular infections caused by bacteria when applied either subconjuctivally or topically at a dose of 2 mg/eye. Furthermore, subconjunctival application of sulfisoxazole could be more efficient for treatment of intraocular infections due to higher absorption of drug and longer remaining time in the eye compared to topical application.
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How to cite this article:

Gokhan Eraslan, Murat Kibar , Dinc Essiz , Fatma Sahindokuyucu and Bilal Cem Liman , 2007. Pharmacokinetic of Sulfisoxazole in Aqueous Humor after Topical and Subconjunctival Application in Dogs. Pakistan Journal of Biological Sciences, 10: 4168-4170.

DOI: 10.3923/pjbs.2007.4168.4170

URL: https://scialert.net/abstract/?doi=pjbs.2007.4168.4170

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