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Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease in Burkina Faso |
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Jacques Simpore,
Denise Ilboudo,
Karou Damintoti,
Luc Sawadogo,
Esposito Maria,
Scott Binet,
Henri Nitiema,
Paul Ouedraogo,
Salvatore Pignatelli and Jean-Baptiste Nikiema |
Abstract:
Where malaria is endemic, there is an unexpected association between
haemoglobinopathies and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.
Their coexistence in a patient with sickle cell disease (SCD) can lead
to hemolytic anemia, hemoglobinuria, sepsis, renal failure and vaso-occlusive
attacks (VOA). The aim of this research was to determine the impact of
G-6-PD deficiency in SCD patients. That is why, we screened haemoglobinopathies
and G-6-PD deficiency in 7 villages and at 10 primary schools in Kadiogo
Province, Burkina Faso. Hemoglobin electrophoresis was performed on blood
from 18,383 people. From these results, we chose 342 subjects for a hemogram
and the measure of the G-6-PD activity. The results were analyzed with
EpiInfo-6 and Spss-10. Statistical significance was set at p<0.05.
We found a prevalence of 28.9% of Sickle Cell Trait (SCT), 1.3% of Major
Sickle Cell Syndromes (MSCS), 12.3% of G-6-PD deficiency among women and
20.5% among men. We did not detect a statistically significant difference
for counts of erythrocytes (p = 0.773), leucocytes (p = 0.227) and reticulocytes
(0.292); hemoglobin levels (p = 0.998); annual vaso-occlusive attacks
(p = 0.869) between persons with SCD having a G-6-PD deficiency and those
with normal G-6-PD activity. According to this study, G-6-PD deficiency
does not seem to increase the severity of SCD. However, these patients
should know their G-6-PD genotype in order to avoid consuming oxidative
drugs that might provoke oxidative stress.
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How to cite this article:
Jacques Simpore, Denise Ilboudo, Karou Damintoti, Luc Sawadogo, Esposito Maria, Scott Binet, Henri Nitiema, Paul Ouedraogo, Salvatore Pignatelli and Jean-Baptiste Nikiema, 2007. Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease in Burkina Faso. Pakistan Journal of Biological Sciences, 10: 409-414.
DOI: 10.3923/pjbs.2007.409.414
URL: https://scialert.net/abstract/?doi=pjbs.2007.409.414
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