
	Pakistan Journal of Biological Sciences
	Year: 2007 \| Volume: 10 \| Issue: 21 \| Page No.: 3875-3879 DOI: 10.3923/pjbs.2007.3875.3879

Effect of Urtica dioica on Morphometric Indices of Kidney in Streptozotocin Diabetic Rats-A Stereological Study

Mohammad Jafar Golalipour , Anneh Mohammad Gharravi , Sorya Ghafari and Mohammad Afshar

Abstract: The aim of the present study was to investigate the effect of Urtica dioica on Morphometric indices of kidney in diabetic rats. Thirty male adult albino wistar rats of 125-175 g divided into control, diabetic and Urtica dioica treatment groups. In treatment Group, diabetic rats received 100 mg kg^-1 daily hydroalcoholic extract of U. dioica intraperitoneally for 4 weeks. After the animals had been sacrified, the kidneys were removed and fixed by formaldehyde, cut horizontally into 1 mm slices and processed, Stained with H and E. Stereological study performed using light microscope and the image projected on a table of olysa software. Cavalieri principle was used to estimate the volume of cortex, medulla and whole kidney. All the grouped data statistically evaluated using Student's t-test, expressed as the Mean±SE. Ration of kidney weight /body weight in diabetes (0.51) and diabetes-extract group (0.67) were higher then control group (0.42). Ratio of kidney volume /body weight in diabetes (350) and diabetes-extract group (348) were higher then control group (323). Volume Ratio of cortex /medulla in diabetes-extract group (1.65) was higher then control (1.34) and diabetes group (1.33). Glomerular area and diameter and proximal tubule diameter in diabetes-Extract group was higher than control and diabetes groups. This study revealed that Urtica dioica has no effect on renal morphometric indices in induced diabetic rats.

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How to cite this article:

Mohammad Jafar Golalipour , Anneh Mohammad Gharravi , Sorya Ghafari and Mohammad Afshar , 2007. Effect of Urtica dioica on Morphometric Indices of Kidney in Streptozotocin Diabetic Rats-A Stereological Study. Pakistan Journal of Biological Sciences, 10: 3875-3879.

DOI: 10.3923/pjbs.2007.3875.3879

URL: https://scialert.net/abstract/?doi=pjbs.2007.3875.3879

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