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Pakistan Journal of Biological Sciences
  Year: 2007 | Volume: 10 | Issue: 21 | Page No.: 3769-3777
DOI: 10.3923/pjbs.2007.3769.3777
 
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Use of Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing to Study Mycobacterium tuberculosis Isolates from East Azarbaijan Province of Iran

Mohammad Asgharzadeh , Mansour Khakpour , Taghi Zahraei Salehi and Hossein Samadi Kafil

Abstract:
The aim of present study was to determine the genotypes of isolates from East Azarbaijan province by this method. We performed (MIRU-VNTR) analysis of strains, isolated from 127 patients during a period of September 2002 to March 2003 in tuberculosis centers of the province. Among 127 isolates, we found 93 distinct MIRU-VNTR patterns, including in 21 clustered patterns and 72 unique patterns from isolated strains. The discriminatory power of MIRU-VNTR typing in present study was high (HGDI = 0.9932) for isolates. In clusters similar patterns of Nakhichevanees patients and Iranian patients was revealed in three clusters which showed Nakhichevanees patients referred to tuberculosis centers of province could be a source for transmission of tuberculosis. Tuberculosis in this province is relatively in good condition. The allelic diversity of our samples was lower than previous studies. These results indicate that MIRU-VNTR can be a useful and first line tool for studying genetic diversity of M. tuberculosis isolates in regional setting such as East Azarbaijan province of Iran.
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How to cite this article:

Mohammad Asgharzadeh , Mansour Khakpour , Taghi Zahraei Salehi and Hossein Samadi Kafil , 2007. Use of Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing to Study Mycobacterium tuberculosis Isolates from East Azarbaijan Province of Iran. Pakistan Journal of Biological Sciences, 10: 3769-3777.

DOI: 10.3923/pjbs.2007.3769.3777

URL: https://scialert.net/abstract/?doi=pjbs.2007.3769.3777

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