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Pakistan Journal of Biological Sciences
  Year: 2007 | Volume: 10 | Issue: 3 | Page No.: 368-372
DOI: 10.3923/pjbs.2007.368.372
 
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A Preliminary Study of Genetic Diversity of MSP-1 Types in Plasmodium falciparum in Southern Province of Sistan Baluchistan of Iran

Zamani Zahra, Razavi Mohammad Reza, Assmar Mehdi, Sadeghi Sedigheh, Pourfallah Fatemeh, Nasoohi Nikoo, Sheibani Ashraf and Raisi Mohammad

Abstract:
Plasmodium falciparum merozoite surface protein-1 (MSP-1) shows extensive antigenic diversity. This is due to the presence of seven variable blocks, five semi-conserved and also five conserved blocks. The variable blocks in the MSP-1 gene are principally dimorphic, displaying either K1 or MAD20 type; except for the block 2 region which is represented by three alleles, an RO33 type in addition to the other two. Allelic diversity is reported to be generated by intra-genic recombination between the variable blocks. A study of allelic variation of MSP-1 gene in Plasmodium falciparum was carried out in the southern province of Sistan Baluchistan in Iran in 2001-2003. Samples were obtained from 30 febrile patients and DNA was extracted and association types between blocks 2 and 6 was identified on each block using specific primers and compared with those from Vietnam, Brazil and Africa. The association types obtained, were similar though less in number than the ones from Vietnam, but more than those from Africa and Brazil.
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How to cite this article:

Zamani Zahra, Razavi Mohammad Reza, Assmar Mehdi, Sadeghi Sedigheh, Pourfallah Fatemeh, Nasoohi Nikoo, Sheibani Ashraf and Raisi Mohammad, 2007. A Preliminary Study of Genetic Diversity of MSP-1 Types in Plasmodium falciparum in Southern Province of Sistan Baluchistan of Iran. Pakistan Journal of Biological Sciences, 10: 368-372.

DOI: 10.3923/pjbs.2007.368.372

URL: https://scialert.net/abstract/?doi=pjbs.2007.368.372

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