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Pakistan Journal of Biological Sciences
  Year: 2007 | Volume: 10 | Issue: 16 | Page No.: 2764-2767
DOI: 10.3923/pjbs.2007.2764.2767
 
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Antinociceptive Activity of Methanolic Extract of Epilobium hirsutum

Fereshteh Pourmorad , Mohammad Ali Ebrahimzadeh , Mitra Mahmoudi and Siavash Yasini

Abstract:
Antinociceptive activity of methanolic extract of aerial parts of Epilobium hirsutum (EH) was determined in the Hot plate and writhing tests in mice. Nearly all extracts showed a dose dependent and marked analgesic activity in mice in the thermal and chemical models of analgesia when compared to the control. Methanol extract at dose of 500 mg kg-1 showed higher activity (97.7% writhing inhibition) than diclofenac 50 mg kg-1 i.p., (77.8%, p<0.05) and morphine 5 mg kg-1 i.p. (91.2%, p<0.05). Methanol extract, in all tested doses (200-500 mg kg-1) significantly increased the pain threshold in hot plate test (p<0.05). EH extract at 200 mg kg-1 showed a similar effect to morphine at 5 mg kg-1. These finding indicate the potential therapeutic use of methanolic extract of aerial parts of EH as a potent antinociceptive agent. LD50 was obtained 1.5±0.1 g kg-1. EH extract did not induce locomotor impairment in mice at any tested doses.
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How to cite this article:

Fereshteh Pourmorad , Mohammad Ali Ebrahimzadeh , Mitra Mahmoudi and Siavash Yasini , 2007. Antinociceptive Activity of Methanolic Extract of Epilobium hirsutum . Pakistan Journal of Biological Sciences, 10: 2764-2767.

DOI: 10.3923/pjbs.2007.2764.2767

URL: https://scialert.net/abstract/?doi=pjbs.2007.2764.2767

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