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Pakistan Journal of Biological Sciences
  Year: 2007 | Volume: 10 | Issue: 16 | Page No.: 2653-2658
DOI: 10.3923/pjbs.2007.2653.2658
 
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The Effect of Palmitic Acid on Spatial Learning and Extinction in Adult Male Rat

Zohreh Hosseinzadeh , Ahmad Ali Moazedi and Rahim Chinipardaz

Abstract:
The aim of the present study is for evaluating the effect of different doses of palmitic acid on spatial learning in T-maze. So, Wister adult male rats were used in five groups and considered 10 rats for each group. The first group as a control group was fed with ordinary diet. Four groups were fed with a diet containing palmitic acid (10%) for 1, 2, 3 and 4 weeks. then rats were trained for spatial learning task by using T-maze at subsequently 9 days based on standard method. The result showed that, spatial learning increased by diet containing palmitic acid 10% for 1, 2 and 3 weeks were significant (p<0.05). However, dietary palmitic acid effect on learning because palmitic acid via palmitoylation modifies numerous important neuronal protein including GAP-43, NMDA receptor, AMPA receptor and these receptors are critical role in learning.
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How to cite this article:

Zohreh Hosseinzadeh , Ahmad Ali Moazedi and Rahim Chinipardaz , 2007. The Effect of Palmitic Acid on Spatial Learning and Extinction in Adult Male Rat . Pakistan Journal of Biological Sciences, 10: 2653-2658.

DOI: 10.3923/pjbs.2007.2653.2658

URL: https://scialert.net/abstract/?doi=pjbs.2007.2653.2658

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