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Pakistan Journal of Biological Sciences
  Year: 2007 | Volume: 10 | Issue: 1 | Page No.: 156-159
DOI: 10.3923/pjbs.2007.156.159
 
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An in vivo Evaluation of the Induction of Abnormal Sperm Morphology by Sulphamethoxypyridazine: Pyrimethamine (Metakelfin®)

O.A. Otubanjo and A.A. Mosuro

Abstract:
The effects of sulphamethoxypyridazine: Pyrimethamine (Metakelfin®) a combination antimalarial drug on mouse sperm head morphology were evaluated in University of Ibadan Veterinary F1 mice. Five different dose levels of 3.85:0.19; 7.7:0.38; 15.4:0.76; 23.1:1.13 and 30.8:1.54 mg kg-1 body weight of sulphamethoxypridazine:pyrimetamine, respectively were administered to the animals by a schedule of 5 consecutive daily intraperitoneal (i.p.) injections. The sperm of the mice from the cauda epididymis were examined 5 weeks after treatment. Metakelfin® induced sperm head abnormalities; however, of the 5 doses sampled; only the 7.7:0.38 mg kg-1 dose, corresponding to 0.5x the human therapeutic dose (HTD0, gave a statistically significant (p>0.05) increase over the negative control value of 2.53% abnormality. All the other dose level treatments did not yield statistically significant increase over the negative control value. The 15.4:0.77 mg kg-1 dose showed 3.5% abnormality and fewer abnormalities than the preceding lower dose. The drug is probably not mutagenic as induction of sperm head abnormality was not dose ependent.
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How to cite this article:

O.A. Otubanjo and A.A. Mosuro, 2007. An in vivo Evaluation of the Induction of Abnormal Sperm Morphology by Sulphamethoxypyridazine: Pyrimethamine (Metakelfin®). Pakistan Journal of Biological Sciences, 10: 156-159.

DOI: 10.3923/pjbs.2007.156.159

URL: https://scialert.net/abstract/?doi=pjbs.2007.156.159

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