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Pakistan Journal of Biological Sciences
  Year: 2006 | Volume: 9 | Issue: 2 | Page No.: 214-216
DOI: 10.3923/pjbs.2006.214.216
 
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Assessment of in vitro activity of Peganum harmala Extract on Plasmodium falciparum Growth Compared with Chloroquine

M. Nateghpour, M. Sharbatkhori, G.H. Edrissian, E. Souri, M. Mohebali, K. Akbarzadeh, A. Motevalli Haghi, M. Satvat and A. Rahimi

Abstract:
In this study antiplasmodial activity of Peganum harmala was assessed against isolates of Chloroquine -sensitive and Chloroquine-resistant plasmodium falciparum, collected from southeast of Iran, in comparison with Chloroquine. Peganum harmala extract in four serial dilutions including 12.5, 25, 50 and 100 μg mL-1 and chloroquine with 8 picomol/well in the test well were evaluated using in vitro method on 23 blood samples from patients infected with Plasmodium falciparum. All of four serial dilutions of Peganum harmala extract could inhibit parasite growth (p<0.05). In comparison with Chloroquine at doses of 12.5 and 25 μg mL-1, it was less effective than Chloroquine, while 50 and 100 μg mL-1 had almost similar results to Chloroquine. P. harmala in doses of 50 and 100 μg mL-1 could decrease Significantly schizont formation of those two strains of P. falciparum parasites which were resistant to chloroquine.
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How to cite this article:

M. Nateghpour, M. Sharbatkhori, G.H. Edrissian, E. Souri, M. Mohebali, K. Akbarzadeh, A. Motevalli Haghi, M. Satvat and A. Rahimi, 2006. Assessment of in vitro activity of Peganum harmala Extract on Plasmodium falciparum Growth Compared with Chloroquine. Pakistan Journal of Biological Sciences, 9: 214-216.

DOI: 10.3923/pjbs.2006.214.216

URL: https://scialert.net/abstract/?doi=pjbs.2006.214.216

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