Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2006 | Volume: 9 | Issue: 8 | Page No.: 1536-1541
DOI: 10.3923/pjbs.2006.1536.1541
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Prevalence of Dyslipidemic Phenotypes Including Hyper-apoB and Evaluation of Cardiovascular Disease Risk in Normocholesterolemic Type 2 Diabetic Patients

Hossain Uddin Shekhar, Hussain Md. Shahjalal , Rumana Ahmed , Mesbah Uddin and Kaniz-Khatun-E-Jannath

Abstract:
Diabetic patients are vulnerable to different lethal diseases including cardiovascular disease, which is still ranked as the number one killer disease in the world. In the present study, the vulnerability of diabetic patients to cardiovascular disease was evaluated considering apoB level as a predictor. Randomly selected Bangladeshi 96 type 2 diabetic patients (M = 48, F = 48) and 49 healthy non-diabetic individuals (M = 37, F = 12) were recruited to compare their anthropometric and biochemical features. Among the diabetic subjects 32 were hypercholesterolemic (LDL-C>150 mg dL-1) and 64 were normocholesterolemic (LDL-C<150 mg dL-1). The biochemical parameters compared were total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein B (apoB). The values for the diabetic patients vs. control were: TC, 214±46 vs. 186±18 mg dL-1; LDL-C, 143±40 vs. 120±18 mg dL-1; TG, 192±79 vs.141±33 mg dL-1 and HDL-C, 35±6 vs. 39±7 mg dL-1; with all p value<0.05. The values for the normocholesterolemic diabetic patients vs. control were: TC, 189±28 vs.186±18 mg dL-1; LDL-C, 120±23 vs. 120±18 mg dL-1; TG, 184±84 vs. 141±33 mg dL-1 and HDL-C, 35±7 vs. 39±7 mg dL-1; of which values of TG and HDL-C were significant. Serum apoB level for the diabetic patients vs. control was 1.15±0.28 vs. 0.926±0.25 g L-1 (p<0.05) and the normocholesterolemic diabetic patients vs. control was 1.06±0.26 vs. 0.926±0.25 g L-1 (p<0.05). 47% (n = 30) of the normocholesterolemic diabetic patients had hyper-apoB, of which 22% were hypertriglyceridemic and 25% were normotriglyceridemic. Surprisingly, hyper-apoB was also found in 14% of control. Thus apoB identified the high-risk phenotypes in normocholesterolemic diabetic patients and it should be used to evaluate the lipidic pattern of these patients.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    The Effect of Hydroalcholic Nettle (Urtica dioica) Extracts on Some Cardiovascular Risk Factors in Patients With Type 2 Diabetes
How to cite this article:

Hossain Uddin Shekhar, Hussain Md. Shahjalal , Rumana Ahmed , Mesbah Uddin and Kaniz-Khatun-E-Jannath , 2006. Prevalence of Dyslipidemic Phenotypes Including Hyper-apoB and Evaluation of Cardiovascular Disease Risk in Normocholesterolemic Type 2 Diabetic Patients. Pakistan Journal of Biological Sciences, 9: 1536-1541.

DOI: 10.3923/pjbs.2006.1536.1541

URL: https://scialert.net/abstract/?doi=pjbs.2006.1536.1541

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

Curve Bottom