Abstract:
Urinary excretion of Salicyluric acid (SUA) was investigated in twelve healthy male volunteers. Urine sample was collected up to 10 h. The concentration of salicyluric acid (SUA) a major metabolite of aspirin was measured colorimetrically. The concentration of salicyluric acid (SUA) (mean±SE) in urine was 200.5±14.9 μg mL-1. Excretion of salicyluric acid was extremely variable and depends upon pH of urine. The results show that the mean±SE values for pH of the urine was 6.24±0.11, amount of drug excreted as salicyluric acid was 63.5±12 mg and percentage of dose excreted was 10.66±1.98. The cumulative amount of dose excreted as salicyluric acid was 191.3±58.2 mg and cumulative percent of dose excreted as salicyluric acid was 62.45±1.06. There is statistically slight variation in urinary excretion of SUA data when compared with foreign investigated values.
Umer Rashid, Haq Nawaz Bhatti , Muhammad Asif Hanif and Najum Rasheed Ahmad , 2006. Determination of Metabolite of Aspirin (Salicyluric Acid) by Colorimetric Method in Human Urine. Pakistan Journal of Biological Sciences, 9: 1004-1008.
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