Effects of Oral Administration of Water Extract of Nigella sativa on Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic Rats


	Pakistan Journal of Biological Sciences
	Year: 2005 \| Volume: 8 \| Issue: 8 \| Page No.: 1152-1156 DOI: 10.3923/pjbs.2005.1152.1156

Effects of Oral Administration of Water Extract of Nigella sativa on Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic Rats

Kamal Mohmoud Saleh Mansi

Abstract: The present study was designed to evaluate the role of a medicinal plant for management of diabetes instead of manufactured drugs that led to much complication. Water extract of Nigella sativa was investigated for hypoglycemic effect in diabetic rats in addition to some hormones related to diabetes mellitus. The extract induced significant reduction in serum glucose from (7.83±1.25) to (6.7±1.10), serum insulin increased from (0.55±0.08) to (0.65±0.06) and testosterone concentration significantly increased in treated diabetic animals (7.58±0.21) compared to diabetic animals (6.63±0.58). The results suggest the beneficial role of N. sativa as hypoglycemic agents and as a protective effect against pancreatic β-cells damage from alloxan induced diabetes in rats by decreasing oxidative stress and preserving pancreatic β-cells integrity and also suggest that the anti diabetic effect of N. sativa may be attributed to increased glucose metabolism. This in turn produces increase level of insulin in serum and testosterone concentration. Which might be related with the functional activity of the reproductive glands and the correlation with the functional state of the pancreatic β-cells.

PDF References Citation Report Citation

RELATED ARTICLES:

•	Utilization of Nigella sativa L. Essential Oil to Improve the Nutritive Quality and Thymoquinone Contents of Baked Products

How to cite this article:

Kamal Mohmoud Saleh Mansi , 2005. Effects of Oral Administration of Water Extract of Nigella sativa on Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic Rats. Pakistan Journal of Biological Sciences, 8: 1152-1156.

DOI: 10.3923/pjbs.2005.1152.1156

URL: https://scialert.net/abstract/?doi=pjbs.2005.1152.1156

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar
		ISI Web of Knowledge
		PubMed
		SCIMAGO
		Thomson ISI

Follow @scialert

Science Alert