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New Coordination Complexes of Chromium as Cytotoxic and Antimicrobial Agents |
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Chanmyia Sheikh,
M. Shamim Hossain ,
Mst. Sabina Easmin ,
M. Saidul Islam ,
M. Aslam Hossain and Mamunur Rashid |
Abstract:
The aim of the present study was to investigate the biocidal activity of seven
new chromium based coordination complexes [Cr(Pht)2 (Glycine)2,
S1], [Cr(Pht)2 (Leucine)2, S2], [Cr(Pht)2
(Cystein)2, S3], [Cr(Pht)2 (Serine)2,
S4], [Cr(Suc)2 (Leucine)2, S5], [Cr(Suc)2
(Cystein)2, S6] and [Cr(Suc)2 (Serine)2,
S7] against Gram-positive and -negative bacteria, fungi and brine shrimp
nauplii. The complexes S1, S3, S4, S6
showed good antibacterial activity at the concentration of 200 μg disc-1
and gave MIC values between 16-64 μg ml-1 against the tested bacteria.
The complexes gave comparatively better antibacterial activity against the Gram-negatives.
S2 did not show any remarkable antifungal activity but others showed
good activity. The brine shrimp were hatched in artificial sea water and exposed
to the complexes to determine mortality rate. LC50 values were calculated
after probit transformation of the resulting data. All the complexes showed better
cytotoxic effect but among them S1 and S3 having LC50
values of 3.31 and 3.63 μg ml-1 showed potent cytotoxic activity when
compared with the reference standard Gallic acid whose LC50 values
was 4.53 μg ml-1.
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How to cite this article:
Chanmyia Sheikh, M. Shamim Hossain , Mst. Sabina Easmin , M. Saidul Islam , M. Aslam Hossain and Mamunur Rashid , 2004. New Coordination Complexes of Chromium as Cytotoxic and Antimicrobial Agents. Pakistan Journal of Biological Sciences, 7: 335-339.
DOI: 10.3923/pjbs.2004.335.339
URL: https://scialert.net/abstract/?doi=pjbs.2004.335.339
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