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Pakistan Journal of Biological Sciences
  Year: 2004 | Volume: 7 | Issue: 10 | Page No.: 1735-1740
DOI: 10.3923/pjbs.2004.1735.1740
 
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Isolation and Identification of an Antifungal Sesquiterpene Alcohol from Amboyna Wood

Irawan W. Kusuma , Tomoko Ogawa , Kazutaka Itoh and Sanro Tachibana

Abstract:
An antifungal compound was isolated from the n-hexane solubles in methanolic extracts of amboyna wood by bioassay-guided fractionation using Pleurotus pulmonarius, a wood-rotting fungus. The compound was identified as β-eudesmol, a sesquiterpene alcohol with an eudesmane skeleton, based on instrumental analyses (Ultraviolet absorption, Mass spectrometry and 1H and 13C-Nuclear Magnetic Resonance spectroscopy) and a melting point test. The compound showed 21% of the antifungal activity of the methanolic extract as a control. Antifungal assays against P. pulmonarius showed that addition of β-eudesmol at different concentrations affected the inhibition of fungal growth. Furthermore, the activity to inhibit the growth of P. pulmonarius seemed to be dependent on the concentration of β-eudesmol.
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How to cite this article:

Irawan W. Kusuma , Tomoko Ogawa , Kazutaka Itoh and Sanro Tachibana , 2004. Isolation and Identification of an Antifungal Sesquiterpene Alcohol from Amboyna Wood. Pakistan Journal of Biological Sciences, 7: 1735-1740.

DOI: 10.3923/pjbs.2004.1735.1740

URL: https://scialert.net/abstract/?doi=pjbs.2004.1735.1740

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