Research Article

**Antibacterial and Cytotoxic Activities of the Metabolites Isolated from a Penicillium Strain**

A.R.M. Ruhul Amin, A. Jabbar and M.A. Rashid

Three antibiotics (RA-1, RA-2 and RA-3) were isolated from the chloroform extract of the fermentation broth of a Penicillium strain of an unidentified species. These compounds exhibited a significant in vitro antibacterial activity against both gram-positive and gram-negative organisms. The MIC values for RA-1, RA-2 and RA-3 were also determined against Bacillus subtilis, Shigella sonnei and Escherichia coli. The chloroform extract also showed strong cytotoxicity in brine shrimp lethality assay.

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A.R.M. Ruhul Amin, A. Jabbar and M.A. Rashid, 2003. Antibacterial and Cytotoxic Activities of the Metabolites Isolated from a Penicillium Strain. Pakistan Journal of Biological Sciences, 6: 1365-1367.

DOI: 10.3923/pjbs.2003.1365.1367

URL: https://scialert.net/abstract/?doi=pjbs.2003.1365.1367

Pakistan Journal of Biological Sciences

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Authors

A.R.M. Ruhul Amin

A. Jabbar

M.A. Rashid

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Research Article

**Antibacterial and Cytotoxic Activities of the Metabolites Isolated from a Penicillium Strain**

How to cite this article

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