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Pakistan Journal of Biological Sciences

Year: 2002 | Volume: 5 | Issue: 7 | Page No.: 784-788
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Authors

Hu Xiu-fang

Chen Ji-shuang

Yang Xian-qiang

Keywords

Research Article

Effect of Tea Polyphenols on Masugi Nephritis of Rabbit

Hu Xiu-fang, Chen Ji-shuang and Yang Xian-qiang
Therapeutic effects of tea polyphenols (TP) on rabbit Masugi nephritis induced by way of subcutaneous immunization were determined by Dexamethasone as a control reagent. TP solutions at three doses (large dose 306mg/Kg; middle dose 102mg/Kg and small dose 34mg/Kg) were administered at 24h intervals for 2 weeks. Urinary protein within 24h, serum creatinine and urea nitrogen of different treatments were quantitatively determined before and after treatment, and kidney specimens were also observed from the euthanized animals. TP reduced the urinary protein excretion, serum creatinine and serum urea nitrogen significantly (P<0.01) in TP-treated rabbits. There were also significant differences in cell number, diameter and also morphological characters of glomerulus, between the treated and non-treated individuals. The effects of TP at large dose were higher than that of Dexamethasone on Masugi nephritis. The above results suggest that TP treatment can reduce symptoms of Masugi nephritis of rabbits.
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