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Pakistan Journal of Biological Sciences
  Year: 2000 | Volume: 3 | Issue: 1 | Page No.: 65-68
DOI: 10.3923/pjbs.2000.65.68
 
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Role of α-Adrenoreceptors In The Regulation of Fore-Stomach Motility in the Goat

T.E.A. Osman and K. A. Al-Busadah

Abstract:
The investigation of the effects of intravenous (i.v.) infusion of α2-adrenoreceptor agonists and antagonists on reticuloruminal motility was carried out in conscious goats. The i.v. administration of the α1-agonist phenylephrine (4 μg kg–1 min–1 for 15 min) or the α2-agonist naphazoline (2.5 μg kg–1 min–1 for 15 min) reduced both frequency and amplitude of reticulum and rumen dorsal sac contractions. Pretreatment of animals with the α1-antagonist prazosin (20 μg kg–1 min–1 for 30 min) prevented the inhibitory effects of phenylephrine on reticuloruminal motility. The effects of naphazoline were prevented by yohimbine, an α2-antagonist at 20 μg kg–1 min–1 for 30 min. Yohimbine, given alone or followed by naphazoline, abolished secondary ruminal dorsal sac contractions. It is concluded that both α12 and α2-adrenoreceptors are involved in the regulation of reticuloruminal motility in the goat. At the dosage of drugs used al and α2-adrenoreceptors appear to play an inhibitory effect on reticuloruminal motility in the goat.
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How to cite this article:

T.E.A. Osman and K. A. Al-Busadah, 2000. Role of α-Adrenoreceptors In The Regulation of Fore-Stomach Motility in the Goat. Pakistan Journal of Biological Sciences, 3: 65-68.

DOI: 10.3923/pjbs.2000.65.68

URL: https://scialert.net/abstract/?doi=pjbs.2000.65.68

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