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Pakistan Journal of Biological Sciences
  Year: 2000 | Volume: 3 | Issue: 9 | Page No.: 1484-1486
DOI: 10.3923/pjbs.2000.1484.1486
 
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Biodisposition Kinetics of Levofloxacin in Female Volunteers Following Oral Administration

Rabis Iqbal, M. Anjum Zia, Tahira Iqbal and Faqir Hussain

Abstract:
Biodisposition kinetics of levofloxacin was determined in 9 female volunteers following oral administration of 500 mg tablets. The blood samples were collected at specific time intervals. Concentration of levofloxacin in plasma was determined by microbiological assay, that was found to be 2.39 μg/ml having 1.75 SD and 75% CV values. The pharmacokinetic parameters were determined according to single compartment open model. The average absorption rate constant was 2.00 L/h while absorption half life was 0.34 hours. Average Cmax and Tmax values were 2.43 mg/L and 1.60 hours while volume of distribution was 177 L. From Tmax studies, it is concluded that absorption is delayed due to non-fasting. It is suggested that levofloxacin can be administered orally with regard to food. It was observed the elimination half life and total body clear values were 7.40 hours and 16.54 h respectively while total area under curve was found to be 30.2 h.mg/L. It is also suggested that elimination half life is not affected by the presence of absence of food.
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How to cite this article:

Rabis Iqbal, M. Anjum Zia, Tahira Iqbal and Faqir Hussain, 2000. Biodisposition Kinetics of Levofloxacin in Female Volunteers Following Oral Administration. Pakistan Journal of Biological Sciences, 3: 1484-1486.

DOI: 10.3923/pjbs.2000.1484.1486

URL: https://scialert.net/abstract/?doi=pjbs.2000.1484.1486

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