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Pakistan Journal of Biological Sciences
  Year: 2000 | Volume: 3 | Issue: 7 | Page No.: 1104-1106
DOI: 10.3923/pjbs.2000.1104.1106
 
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Studies on Biodisposition Kinetics and Urinary Excretion of Kanamycin in Goats

Asma Nafeesa, Tahira Iqbal , Munir A. Shiekh , M. Nawaz and Amer Jamil

Abstract:
The biodisposition kinetin and urinary excretion of kanamycin was investigated in eight normal adult female goats of beetle breed after intravenous close of 5 mg/kg to each gear. After single intravenous administration of kanamycin. in goats, the distribution half-life and biological hall-life had average of 8.1±0.893 min and 2.87±0.12 hrs and ranged between 4.28 to 11.61minutes and 2.44 to 3.37 hrs respectively. The aapparent volume of distribution of kanamycin in goat calculated by area method was 584.6±34.21 mg/kg. The rate constants for Lananivein transfer across compartment 1 to 2, K12 and 2 to 1, K21 were 1.846±0.316 hr–1 and 3.800±0.434 hr and ranged between 1.016 to 3.713 hr–1 and 2.45 to 5.77 hr–1, respectively. Total body clearance of kanarnycin calculated on per kg basis ranged 1.79 to 3.59 ml/min/kg with an average value 2.389±0.194 ml/min/kg, Cumulative urinary excretion as percent of total does excreated at 12 hours was 10.266±1.233. The studies showed variation in pharmacokinetic behaviour of kanamycia in indigenous goats as compared to earlier studies.
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How to cite this article:

Asma Nafeesa, Tahira Iqbal , Munir A. Shiekh , M. Nawaz and Amer Jamil , 2000. Studies on Biodisposition Kinetics and Urinary Excretion of Kanamycin in Goats. Pakistan Journal of Biological Sciences, 3: 1104-1106.

DOI: 10.3923/pjbs.2000.1104.1106

URL: https://scialert.net/abstract/?doi=pjbs.2000.1104.1106

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