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Pakistan Journal of Biological Sciences
  Year: 1999 | Volume: 2 | Issue: 4 | Page No.: 1173-1177
DOI: 10.3923/pjbs.1999.1173.1177
 
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Sex Differences in the Regulation of Plasma Lipids by Apo E Phenotypes in a Group of Young Adolescents

Rajes Qvist, Karuthan Chinna, Anni Mitin and Anuar Zaini

Abstract:
Association between the lipid levels and restriction length polymorphism at the Apolipoprotein E (apo E) gene locus was studied in a sample of unrelated male (91) and female (65) adolescents whose mean age was 17. There was no significant variation in the distribution of the ε4, ε3 and ε2 alleles between the males (ε4=0.148, ε3=0.725, ε2=0.126) and the females (ε4 = 0.161, ε3 = 0.722, ε2 = 0.115). However the contribution of apo E polymorphism on the lipid level was different in both sexes. When the mean lipoprotein levels were compared between the males and females, the females had a significantly higher level of high density lipoprotein cholesterol (HDL-C) (p = 0.008 ) than the males. In the total number of adolescents used in this study, the E3/E2 phenotypes had a significantly (p<0.05) lower level of total and low density lipoprotein (LDL) cholesterol than the E3/E3 and E3/E4 phenotypes. The E3/E4 phenotypes did not increase the level of total and LDL cholesterol. When the number of adolescents were divided into males and females, there were differences in the effect of apo E on the lipoproteins. In both males and females the E3/E2 group had a significantly lower level of total and LDL cholesterol (p<0.05) than the E3/E3 and E3/E4 group. But the effect of the phenotypes on HDL cholesterol was different between the males and females. In the males the HDL-C in the E3/E2 group was significantly higher than the E3/E4 and the E3/E3 group (p<0.05 ) . In the females the HDL-C in the E3/E3 group was significantly higher than the E3/E4 and the E3/E2 groups, (p<0.05). Our data show that the apo E phenotypes modulate the HDL-C differently in the males and females.
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How to cite this article:

Rajes Qvist, Karuthan Chinna, Anni Mitin and Anuar Zaini, 1999. Sex Differences in the Regulation of Plasma Lipids by Apo E Phenotypes in a Group of Young Adolescents. Pakistan Journal of Biological Sciences, 2: 1173-1177.

DOI: 10.3923/pjbs.1999.1173.1177

URL: https://scialert.net/abstract/?doi=pjbs.1999.1173.1177

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