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Pakistan Journal of Biological Sciences
  Year: 1999 | Volume: 2 | Issue: 4 | Page No.: 1100-1101
DOI: 10.3923/pjbs.1999.1100.1101
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B-carotene Lock the Effect of Acrylamide on Liver in the Egyptian Toad

I. A. Sadek and A. Abou-Gabal

Several studies on the harmful effects of chemical pollutants have had an increasing influence on public cancer policy. It has been shown that acrylamide, which is widely used in the synthesis of variety of polymers, induced liver tumor in the Egyptian toad (9 cases out of 50 cases). The liver tumor was diagnosed as hepatocellular carcinoma. In contrast toads treated with acrylamide and B-carotene (3 hr. prior to the carcinogen) completely blocked the hepatocarcinogenesis in toads. However B-carotene was less effective when administered 3 hr, after the carcinogen (acrylamide) in 7 out of 50 cases. It is concluded that B-carotene has an inhibitory effect on hepatocarcinogenesis in toads during initiation.
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How to cite this article:

I. A. Sadek and A. Abou-Gabal, 1999. B-carotene Lock the Effect of Acrylamide on Liver in the Egyptian Toad. Pakistan Journal of Biological Sciences, 2: 1100-1101.

DOI: 10.3923/pjbs.1999.1100.1101






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