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Pakistan Journal of Biological Sciences
  Year: 1998 | Volume: 1 | Issue: 4 | Page No.: 274-276
DOI: 10.3923/pjbs.1998.274.276
 
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Analysis of Metabolites of 4-methyl 2-sulfanilamido-oxazole (Sulfamethoxazole) Excreted in the Urine of Goats

Muhammad Iqbal Baig, Muhammad Nawaz and Muhammad Zafar Iqbal

Abstract:
The urinary excretion and metabolism of 4-Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) were determined in goats following intravenous injection of a single dose 50 mg/kg body weight. The percentage of intravenous dose of 4-Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) excreted in the urine until 24 hour as total amine was 61.0 ± 5.2 per cent, free amine 43.2 ± 4.6 per cent and acetyl amine was 17.8 ± 1.2 per cent. The mean ± SE values for relative percentage of Metabolite I identified as unchanged amine was 42.3 % Metabolite II acetyl amine was 15.67 per cent, Metabolite III hydroxy derivative 18.33 and as conjugated Metabolite were 23.33 per cent. In goats, the urinary excretion and Metabolism of 4-Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) revealed differences appprising as adjustment dosage regimen in the indigenous goats.
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How to cite this article:

Muhammad Iqbal Baig, Muhammad Nawaz and Muhammad Zafar Iqbal, 1998. Analysis of Metabolites of 4-methyl 2-sulfanilamido-oxazole (Sulfamethoxazole) Excreted in the Urine of Goats. Pakistan Journal of Biological Sciences, 1: 274-276.

DOI: 10.3923/pjbs.1998.274.276

URL: https://scialert.net/abstract/?doi=pjbs.1998.274.276

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