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| Combination of Tribulus terrestris, Boerhaavia diffusa and Terminalia chebula Reverses Cisplatin-induced Nephrotoxicity in Wistar Rats |
Uma Shankar Sharma,
Harlokesh Narayan Yadav  ,
Vishwa Mohini Khare,
Surender Singh,
Yogendra Kumar Gupta and Amit K. Tiwari |
Abstract:
Background and Objective: Cisplatin is a potent anti-cancer agent, however, its usage is limited due to its nephrotoxicity. To prevent cisplatin induced kidney toxicity we used a combination of dietary plant extracts, particularly, hydro-alcoholic extract of Tribulus terrestris (TT), Boerhaavia diffusa (BD) and Terminalia chebula (TC) in rats. Materials and Methods: Animals (n = 6 per group) were randomly assigned into six groups: A normal control, cisplatin control, the drug-combination armat doses of 198, 300 and 600 mg kg–1 of equal ratio of each of TT, BD and TC and the combination of 300 mg kg–1 per se group. All treatments were given orally once a day for 10 days. Nephrotoxicity was induced by single dose of cisplatin 8 mg kg–1, i.p on the 7th day. Blood urea nitrogen (BUN), serum creatinine, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx), renal histopathology, liver fatty acid binding protein (L-FAB), kidney injury molecule-1 (Kim-1) and platinum accumulation in kidney tissue were determined. Results: The pre-treatment of the combination of equal ratio of TT, BD and TC at 198, 300 and 600 mg kg–1 significantly (p<0.05) attenuated the cisplatin-induced nephrotoxicity, as indicated by decrease in BUN, serum creatinine, MDA and an increase in the concentration of GSH, SOD and GPx whereas combination100 and 200 mg kg–1 significantly decreases Kim and L-FABP and combination of 600 mg kg–1 significantly decreases the platinum accumulation in treated groups as compare to cisplatin control group. Conclusion: Our results suggest that the combination of TT, BD and TC may be efficacious in attenuating cisplatin-induced nephrotoxicity by decreasing the renal level of platinum, reactive oxygen species (ROS) and oxidative stress.
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How to cite this article:
Uma Shankar Sharma, Harlokesh Narayan Yadav, Vishwa Mohini Khare, Surender Singh, Yogendra Kumar Gupta and Amit K. Tiwari, 2019. Combination of Tribulus terrestris, Boerhaavia diffusa and Terminalia chebula Reverses Cisplatin-induced Nephrotoxicity in Wistar Rats. Pharmacologia, 10: 1-11.
DOI: 10.5567/pharmacologia.2019.1.11
URL: https://scialert.net/abstract/?doi=pharmacologia.2019.1.11
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