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Pharmacologia

Year: 2018 | Volume: 9 | Issue: 4 | Page No.: 169-173
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Authors

Osonuga Ifabunmi Oduyemi

Osonuga Ifabunmi Oduyemi

Adenowo Thomas Kehinde

Keywords

Research Article

Effect of Zidolam (Zidovudine and Lamivudine) on Liver Enzymes and Blood Glucose in Adult Wistar Rats of Both Sexes

Osonuga Ifabunmi Oduyemi Osonuga Ifabunmi Oduyemi's LiveDNA and Adenowo Thomas Kehinde
Background and Objective: Zidolam is an antiretroviral combination therapy for the treatment of HIV infection. This study investigated the impact of highly active anti-retroviral (HAART) on the liver enzymes and blood glucose of adult Wistar rats of both sexes. Materials and Methods: Thirty Wistar rats with body weight (b.wt.,) of 150-230 g were used for the 2-phase study. Solution of the drug in sterile water was administered via oral cannula to the 2 groups of 10 rats (5 males and 5 females) each at daily dose of 1.29 mg/100 g b.wt., respectively for 21 days during phase I. Phase II was a recovery study involving 10 rats (5 males and 5 females) exposed to dose regimen as in phase I and sacrificed after 21-day withdrawal of treatment. The control group of 10 animals (5 males and 5 females) was given sterile water ad-libitum. Serum liver enzymes were determined using kits obtained from Randox Laboratories Ltd, UK. Blood from the cut-tips of the tails of the animals were obtained and glucose values were determined using glucometer. Results: Zidolam caused significant increase (p<0.05) in the liver enzymes: serum pyruvate aminotransferase, serum alkaline phosphatase and serum alanine aminotransferase as well as in blood glucose of the animals. Discontinuation of the drug use however caused gradual recovery of the values of the liver enzymes but the reverse was the case in blood glucose level where there was an increase in the values obtained. Conclusion: The results suggested that Zidolam could induce hepatotoxicity and diabetics in the treated animals and by extension man.
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