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Pharmacologia

Year: 2018 | Volume: 9 | Issue: 4 | Page No.: 149-156
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Authors

Konate Kiessoun

Konate Kiessoun

Mamounata Diao

Dibala I. Crepin

Yomalan Kassi

Alain Souza

Alain Souza

Mamoudou H. Dicko

Keywords

Background and Objective: Out of a large number of plant species used for curing various ailments, there are certain species which are not used widely but occur immensely in major parts of the state. Folklore claims also support the uses of such species for curing various diseases. In the present study one of such species Boswelli dalzielii Hutch have been selected to investigate the in vitro antibacterial and in vivo antipyretic activities of bioactive fraction (dichloromethane fraction) of stem bark from Boswelli dalzielii Hutch in order to confirm the ethnomedicinal use of Boswelli dalzielii Hutch stem bark. Materials and Methods: In vitro antibacterial of dichloromethane fraction of stem bark from Boswelli dalzielii Hutch was assessed using ten bacteria strains MDR (Gram-negative) with free separate methods. About to antipyretic activity, animal model by using albino rats was performed. Results: All test bacteria were susceptible to the dichloromethane fraction of stem bark from Boswelli dalzielii Hutch. Time-kill results showed that after 5 h exposition there was no viable microorganism in the initial inoculum. Moreover, the data analysis indicates that the tested of dichloromethane fraction has significant effects when compared with the standard antibiotic. Concerning antipyretic activity, it was noticed that oral administration of dichloromethane fraction of stem bark induced significant antipyretic activity at a dose of 300 mg kg–1 b. wt and the effect of the high dose 300 mg kg–1 b.wt., nearly similar to that of the standard metamizole sodium (50 mg kg–1 b.wt.) after 3 h. Conclusion: These results therefore justify the traditional use of Boswelli dalzielii Hutch., to treat infectious diseases.
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How to cite this article

Konate Kiessoun, Mamounata Diao, Dibala I. Crepin, Yomalan Kassi, Alain Souza and Mamoudou H. Dicko, 2018. Antibacterial and Antipyretic Properties of Boswelli dalzielii Hutch (Burseraceae) Bioactive Fraction Against Multidrug-Resistant Bacteria. Pharmacologia, 9: 149-156.

URL: https://scialert.net/abstract/?doi=pharmacologia.2018.149.156

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