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Pharmacologia
  Year: 2016 | Volume: 7 | Issue: 2-3 | Page No.: 93-102
DOI: 10.5567/pharmacologia.2016.93.102
 
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Evaluation of the Sensitivity of Measles Virus and Herpes Simplex Virus-1 to Three Locally Available Herbs in Nigeria

R.K. Obi, A.A. Anjorin, B.O. Oke, O.B. Salu, S.A. Adesegun, T.I. Adeleke, O.A. Olayinka, O.S. Ogunsemowo, J.A. Shenge, O.A. Adedeji, B.O. Ajuwon, J.O. Adeleke, K.M. Salawu and S.A. Omilabu

Abstract:
Background and Objective: Viruses cause a variety of illnesses in humans, yet only a few antiviral drugs have been developed. This study was therefore designed to evaluate three potentially useful medicinal plants locally available in Nigeria for possible therapeutic applications against genetically and functionally diverse virus families public health importance. Materials and Methods: Fresh leaves of Bambusa vulgaris, Moringa oleifera and seed of Citrus paridisi were collected from Lagos State, South Western Nigeria. Extraction of the plant materials was done with methanol, chloroform, water and n-hexane using the Soxhlet extractor and concentrated using the rotary evaporator. Results: Results obtained showed that n-hexane extracts of B. vulgaris and M. oleifera inhibited measles virus at the concentrations of 0.125 and 0.016 μg μL–1, respectively. Similarly, while aqueous extract of M. oleifera inhibited measles at 0.125 and 0.063 μg μL–1, aqueous extract of C. paridisi inhibited the virus at 0.031 μg μL–1. While none of the extracts of M. oleifera and C. paridisi produced any inhibitory activity against HSV-1, n-hexane extract of B. vulgaris was able to inhibit the virus at 0.125 μg μL–1. Results of the mechanism of action of the extracts on the replicative cycle of the viruses revealed both adsorption/entry and post infection inhibitors of the viruses. Phytochemical analysis of the extracts revealed the presence of terpenes, alkaloids, flavonoid, tannins, combined and free anthraquinones, cardiac glycosides and saponins. Conclusion: This study has shown that indigenous medicinal plants are invaluable broad spectrum agents in the development of efficacious antiviral cocktails against RNA and DNA viruses of public health importance in Nigeria.
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How to cite this article:

R.K. Obi, A.A. Anjorin, B.O. Oke, O.B. Salu, S.A. Adesegun, T.I. Adeleke, O.A. Olayinka, O.S. Ogunsemowo, J.A. Shenge, O.A. Adedeji, B.O. Ajuwon, J.O. Adeleke, K.M. Salawu and S.A. Omilabu, 2016. Evaluation of the Sensitivity of Measles Virus and Herpes Simplex Virus-1 to Three Locally Available Herbs in Nigeria. Pharmacologia, 7: 93-102.

DOI: 10.5567/pharmacologia.2016.93.102

URL: https://scialert.net/abstract/?doi=pharmacologia.2016.93.102

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