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  Year: 2016 | Volume: 7 | Issue: 4 | Page No.: 202-210
DOI: 10.5567/pharmacologia.2016.202.210
Antimicrobial and Antidiarrheal Activities of Pelargonium luridum (Andrews) Sweet Root Extracts
Sabiu Saheed and Ashafa Anofi Omotayo Tom

Background: Pelargonium luridum is one of the commonly used plants in the Basotho traditional system of medicine for the management of many diseases including diarrhea. This study investigated antimicrobial and antidiarrheal potentials of its root extracts. Methodology: The antimicrobial assays were performed against bacteria and Candida isolates using 96 wells microtitre dilution method, while Wistar rats were employed in the castor oil-induced diarrheal and enteropooling. Results: The ethanol and water extracts inhibited all bacterial and Candida strains at MIC ranging from 0.78-3.13 mg mL–1. The aqueous extract at 75 mg kg–1 b.wt., significantly (p<0.05) reduced the severity of characteristic wet faeces in castor oil-induced diarrheal in Wistar rats by 85% inhibitory activity. The intestinal activity of Na+-K+ATPase was dose-dependently improved, while the level of nitric oxide was markedly attenuated. Similarly, the intestinal propulsion, volume and content were reduced following administration of the extract. The presence of tannins, saponins, flavonoids, steroids and cardiac glycosides could be responsible for the observed activities elicited by the extracts. Conclusion: The results from the present study have shown P. luridum root to be strongly antimicrobial with antidiarrheal activity and therefore, validate its application in the management of infectious diseases by the Basotho traditional medicine practitioners.
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How to cite this article:

Sabiu Saheed and Ashafa Anofi Omotayo Tom, 2016. Antimicrobial and Antidiarrheal Activities of Pelargonium luridum (Andrews) Sweet Root Extracts. Pharmacologia, 7: 202-210.

DOI: 10.5567/pharmacologia.2016.202.210








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