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Pharmacologia
  Year: 2014 | Volume: 5 | Issue: 1 | Page No.: 36-41
 
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Evaluation of the Effects of Citrus aurantifolia (Lime) Juice in Lead-induced Hematological and Testicular Toxicity in Rats

J.S. Aprioku and A.W. Obianime

Abstract:
Background: Citrus aurantifolia (Lime) is a citrus fruit and an excellent source of vitamin C and flavonoids which have unique antioxidant activities. This study evaluates the protective effects of Citrus aurantifolia (Lime) juice on lead-induced toxicity on hematological and reproductive functions and some organ weights in the male rat. Materials and Mathods: The animals were given Pb nitrate (4, 8 or 12 mg kg-1), or 0.1 mL Lime juice+8 mg kg-1 Pb nitrate, or vehicle daily for 28 days by oral gavage. Results: Lead treatment caused lymphocytosis with accompanying neutropenia and anemia. Also, lead significantly increased sperm motility, counts and viability but did alter percentage of abnormal sperm cells (morphology). Testicular weight, as well as liver and kidney weights were equally significantly reduced by lead treatment. Pretreatment with lime, 1 h prior to lead (8 mg kg-1) administration prevented hematological effects of lead. The Citrus juice also inhibited lead-induced reductions in liver and kidney weights but not on testicular weight. Lime pretreatment also inhibited lead-induced reduction in sperm count but did not affect sperm motility and viability. Conclusion: Citrus aurantifolia juice prevents lead-mediated bone marrow toxicity and may also prevent alteration of liver and kidney functions, which may be attributed to the antioxidants (flavonoids and vitamin C) in the plant. On the contrary, Citrus aurantifolia juice does not protect lead-induced testicular toxicity but may rather have potential for promoting testicular dysfunction, which mechanism remains unclear.
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How to cite this article:

J.S. Aprioku and A.W. Obianime, 2014. Evaluation of the Effects of Citrus aurantifolia (Lime) Juice in Lead-induced Hematological and Testicular Toxicity in Rats. Pharmacologia, 5: 36-41.

URL: https://scialert.net/abstract/?doi=pharmacologia.2014.36.41

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