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Pharmacologia

Year: 2014 | Volume: 5 | Issue: 9 | Page No.: 339-350
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Authors

S. Awada

S. Rachidi

A. Al-Hajje

R.K. Zeidan

N. Bou Kansour

C. Abboud

W. Bawab

P. Salameh

Keywords

Background: Gastroesophageal reflux disease (GERD) is a common disorder which has a detrimental impact on patients’ quality of life. The Reflux-Qual Short form (RQS) is an eight-item instrument, developed for measurement of GERD’s effect on quality of life. AIM: The primary objective of the study was to validate the RQS in Lebanon, a secondary objective was to investigate the potential risk factors of GERD in the same sample. Methods: A questionnaire was administered face-to face to a sample of Lebanese adults all over Lebanon. Participants were classified as GERD positive and GERD negative based on the presence of heartburn and/or regurgitation at least once per week and/or physician-made diagnosis of GERD. Psychometric properties of the RQS were evaluated, significant predictors of lower quality of life and GERD associates were assessed. Results: The RQS showed a high internal consistency (Cronbach’s alpha = 0.967) and an adequate factorial structure. A higher number of symptoms (β = -0.364), a disease of the digestive system (β = -0.186), the presence of GERD (β = -0.176), having a worse psychological state (β = -0.105), a higher BMI (β = -0.091) and the presence of any heart or artery disease (β = -0.088) or renal disease (β = -0.087) were associated with lower RQS scores. The most notable risk factors of GERD were older age (ORa = 3.10), higher education (ORa = 2.53), thyme (ORa = 1.73), citrus (ORa = 1.34), chocolate (ORa = 1.29), garlic or onions (ORa = 1.51) and cucumber (ORa = 1.60) consumption and carbonated beverages (ORa = 1.62) were associated with the occurrence of GERD. Drinking milk (Ora = 0.72) and the increasing meals frequency (ORa = 0.60) had protective effects on GERD occurrence. Subjects with asthma (ORa = 8.35), with any disease related to the digestive system (ORa = 4.97), with diabetes mellitus (ORa = 2.74) and those who had a family member suffering from GERD (ORa = 3.73) tended to be more prone to get GERD. Moreover, DifenB12® (betamethasone, diclofenac, vitamin B12) (ORa = 69.186), ibuprofen preparations (ORa = 2.76 and ORa = 2.12) and iron supplements (ORa = 1.62) were associated with higher GERD. Conclusion: The RQS is a simple, 8-items instrument specific to GERD, sensitive to between-subject differences. The frequency and multitude of GERD symptoms lowered the RQS score. Some socio-demographic factors, lifestyle habits, concomitant diseases and certain drugs were associated with increased GERD risk.
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How to cite this article

S. Awada, S. Rachidi, A. Al-Hajje, R.K. Zeidan, N. Bou Kansour, C. Abboud, W. Bawab and P. Salameh, 2014. Gastro-esophageal Reflux Disease in Lebanese Adults: Effects on Quality of Life and Correlates. Pharmacologia, 5: 339-350.

URL: https://scialert.net/abstract/?doi=pharmacologia.2014.339.350

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