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Pharmacologia
  Year: 2013 | Volume: 4 | Issue: 4 | Page No.: 311-319
DOI: 10.5567/pharmacologia.2013.311.319
Protein-Tyrosine Phosphatase 1β Inhibitory Activity Potential in Vegetables’ Juice
Ashok Kumar Tiwari, Domati Anand Kumar, Pisupati Sri Rajeshwari Sweeya, Kondepudi Manikanta Abhinay, Anusha Chauhan Hanumantha, Vadala Lavanya, Ambati Sudharshana Raju, Kayyuru Sireesha and Konda Pavithra

Abstract:
Aim: Insulin resistance and leptin resistance are hallmarks in common for development of type 2 diabetes mellitus (T2DM) and obesity. Both these conditions are associated with increased activity and expression of Protein-Tyrosine Phosphatase 1β (PTP 1β). Therefore, inhibition of PTP 1β activity or down-regulation of its expression has become an attractive area of therapeutics development in order to ameliorate phenomenon of insulin and leptin resistance. This research analysed and assessed PTP 1β inhibitory activity in thirteen easily available and commonly consumed vegetables’ juice. Materials and Methods: Percentage yield of the juice, total polyphenol and total protein concentrations were estimated in fresh juice of vegetables. PTP 1β inhibitory activity by vegetables’ juice in cytosolic supernatant of goat liver and skeletal muscle was determined. Results: Wide variations in juice yield, total polyphenol and protein concentration in vegetables’ juice were found. Juice of Ridge Gourd (RG) and Yellow Pumpkin (YP) were rich source of both, polyphenol and protein. Green Cucumber (GC), Bottle Gourd (BG), Snake Gourd (SG), RG, Radish (RD), Carrot (CT), Noolkol (NK) and Yellow Cucumber (YC) displayed reversible inhibition of PTP 1β. Juice of vegetables YP, Ivy Gourd (IG), Chayote (CH), Ash Gourd (AG) and Banana Stem (BS) displayed irreversible PTP 1β inhibition. Based on the order of PTP 1β inhibition potential in both liver and skeletal muscle, juice of RD and BG were identified most potent. Conclusion: This research finds vegetables’ juice as potent source of PTP 1β inhibitor and may offer cost effective therapeutic potential in reducing risk of insulin resistance and development of T2DM.
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How to cite this article:

Ashok Kumar Tiwari, Domati Anand Kumar, Pisupati Sri Rajeshwari Sweeya, Kondepudi Manikanta Abhinay, Anusha Chauhan Hanumantha, Vadala Lavanya, Ambati Sudharshana Raju, Kayyuru Sireesha and Konda Pavithra, 2013. Protein-Tyrosine Phosphatase 1β Inhibitory Activity Potential in Vegetables’ Juice. Pharmacologia, 4: 311-319.

DOI: 10.5567/pharmacologia.2013.311.319

URL: https://scialert.net/abstract/?doi=pharmacologia.2013.311.319

 
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