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Pharmacologia

Year: 2013 | Volume: 4 | Issue: 3 | Page No.: 249-253
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Authors

Veni Bharti

Kiran

Surendra Kumar Sharma

Sumitra Singh

Keywords

Research Article

Evaluation of the Memory and Learning Improving Effects of Benincasa hispida Seeds in Mice

Veni Bharti
Department of Pharmaceutical Sciences, Guru Jambheshwer University of Science and Technology, Hisar, Haryana, India
Kiran
Department of Pharmaceutical Sciences, Guru Jambheshwer University of Science and Technology, Hisar, Haryana, India
Surendra Kumar Sharma
Department of Pharmaceutical Sciences, Guru Jambheshwer University of Science and Technology, Hisar, Haryana, India
Sumitra Singh
Department of Pharmaceutical Sciences, Guru Jambheshwer University of Science and Technology, Hisar, Haryana, India
Background: Management of cognitive disorders like dementia and Alzheimer’s disease has been challenging since no potential drug is available with proved efficacy. Some nootropic drugs like piracetam, aniracetam and cholinesterase inhibitors such as Donepezil® have found to exhibit severe toxic effects in elderly. Aim: In the present study, we assessed the nootropic potential of aqueous and methanol extract of Benincasa hispida on various behavioural models. Method: The young animals treated with aqueous and methanol extract (200 and 400 mg kg-1) showed dose-dependent reduction in transfer latency at both 9th and 10th day by elevated plus maze, morris water maze and object recognition task. Conclusion: From the results, it was concluded that methanolic extract of Benincasa hispida can be a useful memory restorative agent in the treatment of dementia.
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