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Pharmacologia
  Year: 2012 | Volume: 3 | Issue: 12 | Page No.: 693-699
DOI: 10.5567/pharmacologia.2012.693.699
Pharmacological Effects of Garcinia kola Seed Powder on Blood Sugar, Lipid Profile and Atherogenic Index of Alloxan-induced Diabetes in Rats
E.C.C. Udenze, V.B. Braide, C.N. Okwesilieze and G.C. Akuodor

Abstract:
Objective: The pharmacological effects of Garcinia kola seed Powder (GKP) on blood sugar, lipid profile and atherogenic index of diabetic rats were studied. Materials and Methods: Thirty male albino Wistar rats were divided into six groups of five animals per group. The first two groups: non-diabetic control and non-diabetic treated were normal animals and orally given normal saline and 600 mg kg-1 b.wt. GKP respectively. The last four groups which were made diabetic using alloxan monohydrate had one diabetic untreated group, that received normal saline and three diabetic treated groups which received 300, 600 and 900 mg kg-1 b.wt. of GKP orally, respectively. At a single dose of treatment, blood was collected through tail vein puncture and blood glucose concentration measured with glucometer at 0, 2, 4, 6 and 8 h after which it was continued for 21 days. At the end of the treatment period, the animals were sacrificed and blood collected via cardiac puncture from where serum was recovered for lipid profile analysis. Results: GKP treatment significantly lowered blood glucose and improved lipid profile and atherogenic index of diabetic rats. This investigation therefore portrays GKP as an antidiabetic, antilipidemic and anti-atherogenic agent with a tremendous potential to protect against coronary heart disease.
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How to cite this article:

E.C.C. Udenze, V.B. Braide, C.N. Okwesilieze and G.C. Akuodor, 2012. Pharmacological Effects of Garcinia kola Seed Powder on Blood Sugar, Lipid Profile and Atherogenic Index of Alloxan-induced Diabetes in Rats. Pharmacologia, 3: 693-699.

DOI: 10.5567/pharmacologia.2012.693.699

URL: https://scialert.net/abstract/?doi=pharmacologia.2012.693.699

 
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