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Pharmacologia

Year: 2012 | Volume: 3 | Issue: 10 | Page No.: 535-538
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Authors

Seyed Mehdi Razavi

Gholamreza Zarrini

Ghader Molavi

Keywords

Research Article

The Evaluation of Some Biological Activity of Mentha longifolia (L.) Huds Growing Wild in Iran

Seyed Mehdi Razavi, Gholamreza Zarrini and Ghader Molavi
Mentha longifolia (L.) Huds. is a perennial rhizomatous herb distributed from Southern Africa, Europe, the Mediterranean region and eastwards into Asia. Mentha species are also generally known under name of Puneh in Iran where they have been used for centuries as tonics, carminative, digestive, stomachic, antispasmodic and anti-inflammatory agent in folk medicine. In the present work, we study antimicrobial and cytotoxic activity of the plant extracts. The antibacterial and antifungal activity of the plant extracts were evaluated using disk diffusion method. We evaluated cytotoxicity of M. longifolia with MTT assay, as well as. Present finding revealed that the methanol extract of the plant leaves were active against all tested bacteria and fungi. The highest inhibitory effect was observed against Erwinia carotovora, a common plant pathogen bacteria, with MIC value of 128 μg mL-1 and inhibition zone of 41 mm. The extract also exhibited high antibacterial activity with MIC value rang of 192-512 μg mL-1 and inhibition zone of 34-40 mm against S. aureus, Enterococcus faecalis, Streptococcus agalactiae and Escherichia coli. The methanol extract of the plant displayed modest to strong antifungal activity against Candida kefyr, Candida albicans, Sclerotinia sclerotiorum and Aspergillus niger with MIC value range of 576-800 μg mL-1 and inhibition zone of 26-33 mm. Our finding showed that M. longifolia methanol extract has cytotoxic activity. The extract reduced the viability of McCoy cells with RC50 value of 1.92 mg mL-1. It was be concluded that M. longifolia extract cab be used as an antiseptic agent and may be also a good candidate to construction of a new plant biopesticide.
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