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Kidney Research Journal
  Year: 2016 | Volume: 6 | Issue: 1 | Page No.: 1-8
DOI: 10.3923/krj.2016.1.8
 
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Ameliorative Potential of Alcoholic Red Wine Against CCl4-induced Renalotoxicity in Albino Rats
E.O. Ibukun and G.O. Oladipo

Abstract:
Objective: This study was aimed at evaluating the renaloprotective effect of alcoholic red wine against CCl4-induced toxicity. Methodology: In vitro antioxidant activity of the alcoholic red wine was typified by total antioxidant activity, ABTS, DPPH and hydroxyl radicals, reducing power and metal chelating activities. In vivo evaluation of the ameliorative effect of alcoholic red wine against CCl4-renalotoxicity was experimented on kidney function by the profiling of biochemical indices, such as alkaline phosphatase (ALP) activity, creatinine clearance, Total Protein (TP) and the antioxidant status evaluated by activities of superoxide dismustase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and glutathione-S-transferase (GST). Results: The results revealed that extracts of red wine had total antioxidant activity value of 96.57±6.441 mg g–1 AAE. Conclusion: The study revealed that the alcoholic red wine has ameliorative effect, which did not nullify the effect of the toxicological stress in all of the results.
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How to cite this article:

E.O. Ibukun and G.O. Oladipo, 2016. Ameliorative Potential of Alcoholic Red Wine Against CCl4-induced Renalotoxicity in Albino Rats. Kidney Research Journal, 6: 1-8.

DOI: 10.3923/krj.2016.1.8

URL: https://scialert.net/abstract/?doi=krj.2016.1.8

 
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