Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Kidney Research Journal
  Year: 2011 | Volume: 1 | Issue: 1 | Page No.: 13-23
DOI: 10.3923/krj.2011.13.23
Renoprotective Effect of Date Fruit Extract on Ochratoxin (A) Induced-oxidative Stress in Distal Tubules of Rat: A Light and Electron Microscopic Study
A. Ali, S. Abdu and S. Alansari

Abstract:
Nowadays, people's exposure to mycotoxin such was continuously on the rise more and more. Theses compounds had induced an excessive production of free radicals which were responsible for several cell alterations in the organism. Recent investigations had proved the crucial role of nutritional antioxidants to prevent the damage caused by toxic compounds. In this study, we investigated the role of date fruit extract in protection against oxidative damage and distal tubules toxicity induced by chronic exposure to ochratoxin (A) (OTA). The animals were assigned into four groups (n = 8) including control and test groups. Control group received sodium bicarbonate and the animals in the test groups received (289 μg OTA kg-1 b.wt. day-1), (1 mg Ajwa kg-1 b.wt. day-1) and (289 μg OTA kg-1 b.wt. day-1+1 mg Ajwa kg-1 b.wt. day-1), respectively during 28 consecutive days. Oral administration of OTA caused nepherotoxicity as monitored by histological alterations marked by appearance of numerous apoptotic cells with swollen mitochondria and disintegrated membranes. Surprisingly, histopathological examinations showed that date, exerted a protective effect on OTA-induced damages, as revealed by improvement of histopathology changes whereas, in Ajwa date extract+OTA group the severity of the lesions was significantly reduced. In conclusion, this data indicated that OTA, at least partly by interfering in oxidative stress system, exerted its toxic effects on distal tubules whereas in vivo date with antioxidant properties could fairly protected rats against OTA toxic effects and be useful for the prevention of oxidative stress induced nepherotoxicity.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Berberine Improves Kidney Injury Following Renal Ischemia Reperfusion in Rats
  •    Evaluation of Antiangiogenic, Cytotoxic and Antioxidant Effects of Syzygium aromaticum L. Extracts
  •    Nutritional Composition and in vitro Evaluation of the Antioxidant Properties of Various Dates Extracts (Phoenix dactylifera L.) from Libya
How to cite this article:

A. Ali, S. Abdu and S. Alansari, 2011. Renoprotective Effect of Date Fruit Extract on Ochratoxin (A) Induced-oxidative Stress in Distal Tubules of Rat: A Light and Electron Microscopic Study. Kidney Research Journal, 1: 13-23.

DOI: 10.3923/krj.2011.13.23

URL: https://scialert.net/abstract/?doi=krj.2011.13.23

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 

       

       

Curve Bottom