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Journal of Pharmacology and Toxicology

Year: 2023 | Volume: 18 | Issue: 3 | Page No.: 120-131
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Authors

Chima Innocent Ugbor

Chima Innocent Ugbor

Geoffrey Okoeguale

Uzochiamaka Sonsy Nwobodo

Nneka J. Duhu

Kenneth Emeka Udeme

Solomon N. Ekoh

Emmanuel Ikechukwu Odo

Gregory John Paul Aji

Keywords

Background and Objective: Tobacco snuff in Nigeria is the blended dried tobacco left with potash. This substance has been proven to cause systemic distortions and its consumption is unhealthy, thus tobacco snuff-induced hepatic alterations were investigated. Materials and Methods: In this study (8 weeks), liver histological changes were investigated after tobacco snuff ingestion. Forty-two experimental animals (Wister rats) were involved and they were divided into groups A (control), group B (test group 1), C (test group 2) and D (test group 3). The test groups were further divided into four groups receiving 2.4, 4.8 and 7.2 g graded doses of tobacco snuff for the experimental duration of 8 weeks. The experimental duration was phased into 2 weeks and at the end of each 2 weeks, liver organs were harvested for analysis. Results: Hepatic tissue damage was observed through examination of the stained paraffin-embedded sections. Edematous changes with parenchymal erosion as well as cellular necrosis, vacuolations, hemorrhagic exudations, inflammatory cellular infiltration, severe cellular infiltration, cellular degeneration and distortions of parenchymal tissue architecture were observed among the experimental animals. Conclusion: The present results showed that tobacco snuff is capable of inducing severe liver damage and the observed damages were dose and duration-dependent.
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Chima Innocent Ugbor, Geoffrey Okoeguale, Uzochiamaka Sonsy Nwobodo, Nneka J. Duhu, Kenneth Emeka Udeme, Solomon N. Ekoh, Emmanuel Ikechukwu Odo and Gregory John Paul Aji, 2023. Tobacco Snuff-Induced Hepatic Alterations. Journal of Pharmacology and Toxicology, 18: 120-131.

DOI: 10.3923/jpt.2023.120.131

URL: https://scialert.net/abstract/?doi=jpt.2023.120.131

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